Triple-negative breast cancer (TNBC) poses a significant clinical challenge due to its
propensity for metastasis and poor prognosis. TNBC evades the body's immune system …

Triple-negative breast cancer (TNBC) is the most violent class of tumor and accounts for 20–
24% of total breast carcinoma, in which frequently rare mutation occurs in high frequency …

Triple-negative breast cancer (TNBC) is a metastatic disease and a formidable treatment
challenge as it does not respond to existing therapies. Epigenetic regulators play a crucial …

Of all gynecologic cancers, epithelial-ovarian cancer (OCa) stands out with the highest
mortality rates. Despite all efforts, 90% of individuals who receive standard surgical and …

Signal transducer and activator of transcription 3 (STAT3), a transcription factor, regulates
gene levels that are associated with cell survival, cell cycle, and immune reaction. It is …

Endometriosis is an estrogen dominant, chronic inflammatory disease characterized by the
growth of endometrial-like tissue outside of the uterus. The most common symptoms …

Vorinostat (SAHA) is a histone deacetylase inhibitor that exerts its effects through epigenetic
regulation. Specifically, SAHA can inhibit the proliferation of triple-negative breast cancer …

The dysregulation of leukemia inhibitory factor (LIF) and its cognate receptor (LIFR) has
been associated with multiple cancer initiation, progression, and metastasis. LIF plays a …

Histone deacetylase inhibitors (HDACis) show beneficial effects on different hematological
malignancy subtypes. However, their impacts on treating solid tumors are still limited due to …

Breast cancer has an extremely high incidence in women, and its morbidity and mortality
rank first among female tumors. With the increasing development of molecular biology and …