Kisspeptin is vital for the neuroendocrine regulation of GNRH secretion. Kisspeptin neurons
are now recognized as a central pathway responsible for conveying key homeostatic …

Inflammation and oxidative stress are involved in age-related macular degeneration (AMD)
and possibly associated with an activation of neuronal apoptosis inhibitor protein/class II …

Background The wingless-type MMTV integration site (Wnt) signaling is a group of signal
transduction pathways. In canonical Wnt pathway, Wnt ligands bind to low-density …

Age-related macular degeneration (AMD) is a common yet complex retinal degeneration
that causes irreversible central blindness in the elderly. Pathology is widely believed to …

Purpose: The leading cause of severe visual loss world-wide is age-related macular
degeneration. Although anti-Vascular Endothelial Growth Factor agents have significantly …

Purpose: Nondegradable fluorophores that accumulate as deleterious lipofuscin of RPE are
involved in pathological mechanisms leading to the degeneration of RPE in AMD. A2E, a …

Background and Aims Age-related macular degeneration (AMD) is an important cause of
visual impairment in elderly persons. AMD is a multifactorial disease in which both …

Pigment epithelium derived factor (PEDF) expression has been described in many organs
as showing neurotrophic, anti-angiogenic, anti-apoptotic, anti-inflammatory, anti-oxidant and …

Reproductive aging is a biological phenomenon that is seen in women, noted by a
progressive decline in ovarian function and a decrease in both the quantity and quality of …

Age related macular degeneration is the commonest cause of blindness in the western
world and current treatment regimens represent a significant output for national health …