Nonalcoholic fatty liver disease 2020: the state of the disease
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease, with a worldwide
prevalence of 25%. In the United States, NAFLD and its subtype, nonalcoholic …
prevalence of 25%. In the United States, NAFLD and its subtype, nonalcoholic …
Alpha1-Antitrypsin Deficiency
P Strnad, NG McElvaney… - New England Journal of …, 2020 - Mass Medical Soc
Alpha1-Antitrypsin Deficiency AAT is a protease inhibitor targeting neutrophil elastase. It
prevents the destruction of tissue, particularly in the lung, from elastase activity. AAT …
prevents the destruction of tissue, particularly in the lung, from elastase activity. AAT …
[HTML][HTML] Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort☆
Background & Aims Genetic factors associated with non-alcoholic fatty liver disease
(NAFLD) remain incompletely understood. To date, most genome-wide association studies …
(NAFLD) remain incompletely understood. To date, most genome-wide association studies …
Recent advances in alcohol-related liver disease (ALD): summary of a Gut round table meeting
Alcohol-related liver disease (ALD), which includes a range of disorders of different severity
and is one of the most prevalent types of liver disease worldwide, has recently regained …
and is one of the most prevalent types of liver disease worldwide, has recently regained …
[HTML][HTML] Diagnosis and management of secondary causes of steatohepatitis
R Liebe, I Esposito, HH Bock, S Vom Dahl, J Stindt… - Journal of …, 2021 - Elsevier
The term non-alcoholic liver disease (NAFLD) was originally coined to describe hepatic fat
deposition as part of the metabolic syndrome. However, a variety of rare hereditary liver and …
deposition as part of the metabolic syndrome. However, a variety of rare hereditary liver and …
[PDF][PDF] Genetic pathways in nonalcoholic fatty liver disease: insights from systems biology
Nonalcoholic fatty liver disease (NAFLD) represents a burgeoning worldwide epidemic
whose etiology reflects multiple interactions between environmental and genetic factors …
whose etiology reflects multiple interactions between environmental and genetic factors …
Loss of hepatic Mboat7 leads to liver fibrosis
VR Thangapandi, O Knittelfelder, M Brosch… - Gut, 2021 - gut.bmj.com
Objective The rs641738C> T variant located near the membrane-bound O-acyltransferase
domain containing 7 (MBOAT7) locus is associated with fibrosis in liver diseases, including …
domain containing 7 (MBOAT7) locus is associated with fibrosis in liver diseases, including …
Alpha-1 antitrypsin deficiency: A re-surfacing adult liver disorder
M Fromme, CV Schneider, C Trautwein… - Journal of …, 2022 - Elsevier
Summary Alpha-1 antitrypsin deficiency (AATD) arises from mutations in the SERPINA1
gene encoding alpha-1 antitrypsin (AAT) that lead to AAT retention in the endoplasmic …
gene encoding alpha-1 antitrypsin (AAT) that lead to AAT retention in the endoplasmic …
Genome‐wide association study and meta‐analysis on alcohol‐associated liver cirrhosis identifies genetic risk factors
TH Schwantes‐An, R Darlay, P Mathurin… - …, 2021 - Wiley Online Library
Background and Aims Only a minority of heavy drinkers progress to alcohol‐associated
cirrhosis (ALC). The aim of this study was to identify common genetic variants that underlie …
cirrhosis (ALC). The aim of this study was to identify common genetic variants that underlie …
Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes
Serum concentration of hepatic enzymes are linked to liver dysfunction, metabolic and
cardiovascular diseases. We perform genetic analysis on serum levels of alanine …
cardiovascular diseases. We perform genetic analysis on serum levels of alanine …