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[PDF][PDF] Cre recombinase: the universal reagent for genome tailoring
In September 1998 the workshop for “Conditional Genome Alterations” in Cold Spring
Harbor had a simple but important take-home message:“Cre works”(Rossant and McMahon …
Harbor had a simple but important take-home message:“Cre works”(Rossant and McMahon …
Molecular mechanisms of memory acquisition, consolidation and retrieval
Memory is often considered to be a process that has several stages, including acquisition,
consolidation and retrieval. Memory can be modified further through reconsolidation and …
consolidation and retrieval. Memory can be modified further through reconsolidation and …
Mesolimbic dopamine signals the value of work
Dopamine cell firing can encode errors in reward prediction, providing a learning signal to
guide future behavior. Yet dopamine is also a key modulator of motivation, invigorating …
guide future behavior. Yet dopamine is also a key modulator of motivation, invigorating …
Transgenic mice with hematopoietic and lymphoid specific expression of Cre
Abstract Bacteriophage P1 Cre/loxP based systems can be used to manipulate the genomes
of mice in vivo and in vitro, allowing the generation of tissue‐specific conditional mutants …
of mice in vivo and in vitro, allowing the generation of tissue‐specific conditional mutants …
[HTML][HTML] Essential role for TrkB receptors in hippocampus-mediated learning
Brain-derived neurotrophic factor (BDNF) and its receptor TrkB regulate both short-term
synaptic functions and long-term potentiation (LTP) of brain synapses, raising the possibility …
synaptic functions and long-term potentiation (LTP) of brain synapses, raising the possibility …
Pancreatic exocrine duct cells give rise to insulin-producing β cells during embryogenesis but not after birth
A longstanding unsettled question is whether pancreatic β cells originate from exocrine duct
cells. We have now used genetic labeling to fate map embryonic and adult pancreatic duct …
cells. We have now used genetic labeling to fate map embryonic and adult pancreatic duct …
hGFAP‐cre transgenic mice for manipulation of glial and neuronal function in vivo
With the goal of performing astrocyte‐specific modification of genes in the mouse, we have
generated a transgenic line expressing Cre recombinase under the control of the human …
generated a transgenic line expressing Cre recombinase under the control of the human …
Disruption of CREB function in brain leads to neurodegeneration
Control of cellular survival and proliferation is dependent on extracellular signals and is a
prerequisite for ordered tissue development and maintenance. Activation of the cAMP …
prerequisite for ordered tissue development and maintenance. Activation of the cAMP …
Conditional control of gene expression in the mouse
One of the most powerful tools that the molecular biology revolution has given us is the
ability to turn genes on and off at our discretion. In the mouse, this has been accomplished …
ability to turn genes on and off at our discretion. In the mouse, this has been accomplished …
Preclinical models: status of basic research in depression
Approximately one half-century ago several classes of medications, discovered by
serendipity, were introduced for the treatment of depression and bipolar disorder. These …
serendipity, were introduced for the treatment of depression and bipolar disorder. These …