Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …

Infectious diseases caused by pathogens including viruses, bacteria, fungi, and parasites
are ranked as the second leading cause of death worldwide by the World Health …

Abstract The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell–
mediated responses in inflammation for more than a decade after it was first identified …

Chemokines and cytokines are critical for initiating and coordinating the organized and
sequential recruitment and activation of cells into Mycobacterium tuberculosis-infected …

Tumor-associated tertiary lymphoid structures (TA-TLS) are associated with enhanced
patient survival and responsiveness to cancer therapies, but the mechanisms underlying …

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) latently infects
approximately one-fourth of the world's population. The immune mechanisms that govern …

Lymph node stromal cells coordinate the adaptive immune response in secondary lymphoid
organs, providing both a structural matrix and soluble factors that regulate survival and …

Tuberculosis (TB) remains one of the greatest threats to human health. The causative
bacterium, Mycobacterium tuberculosis (Mtb), is acquired by the respiratory route. It is …

Type 2 diabetes mellitus (DM) is a major risk factor for the development of active pulmonary
tuberculosis (TB), with development of DM pandemic in countries where TB is also endemic …

Pulmonary granulomas are widely considered the epicenters of the immune response to
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). Recent animal …