Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Nrf2 and its endogenous inhibitor, Keap1, function as a ubiquitous, evolutionarily conserved
intracellular defense mechanism to counteract oxidative stress. Sequestered by cytoplasmic …

Autophagy is a conserved process that catabolizes intracellular components to maintain
energy homeostasis and to protect cells against stress. Autophagy has crucial roles during …

Mitochondrial quality control is essential in highly structured cells such as neurons and
muscles. In skeletal muscle the mitochondrial fission proteins are reduced in different …

Mitochondrial dysfunction occurs during aging, but its impact on tissue senescence is
unknown. Here, we find that sedentary but not active humans display an age-related decline …

The dynamic coordination of processes controlling the quality of the mitochondrial network is
crucial to maintain the function of mitochondria in skeletal muscle. Changes of mitochondrial …

Various diseases can cause skeletal muscle atrophy, usually accompanied by inflammation,
mitochondrial dysfunction, apoptosis, decreased protein synthesis, and enhanced …

Once considered exclusively the cell's powerhouse, mitochondria are now recognized to
perform multiple essential functions beyond energy production, impacting most areas of cell …

Stresses like low nutrients, systemic inflammation, cancer or infections provoke a catabolic
state characterized by enhanced muscle proteolysis and amino acid release to sustain liver …

Mitochondrial fission and fusion play critical roles in maintaining functional mitochondria
when cells experience metabolic or environmental stresses. Fusion helps mitigate stress by …