Lipids and lipid derivatives for RNA delivery

Y Zhang, C Sun, C Wang, KE Jankovic… - Chemical reviews, 2021 - ACS Publications
RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …

The biological applications of DNA nanomaterials: current challenges and future directions

W Ma, Y Zhan, Y Zhang, C Mao, X **e… - Signal transduction and …, 2021 - nature.com
DNA, a genetic material, has been employed in different scientific directions for various
biological applications as driven by DNA nanotechnology in the past decades, including …

DNA functional materials assembled from branched DNA: design, synthesis, and applications

Y Dong, C Yao, Y Zhu, L Yang, D Luo… - Chemical Reviews, 2020 - ACS Publications
DNA is traditionally known as a central genetic biomolecule in living systems. From an
alternative perspective, DNA is a versatile molecular building-block for the construction of …

Nuclease resistance of DNA nanostructures

AR Chandrasekaran - Nature Reviews Chemistry, 2021 - nature.com
DNA nanotechnology has progressed from proof-of-concept demonstrations of structural
design towards application-oriented research. As a natural material with excellent self …

Rationally engineered nucleic acid architectures for biosensing applications

M **ao, W Lai, T Man, B Chang, L Li… - Chemical …, 2019 - ACS Publications
Development of biosensing platforms plays a key role in research settings for identification
of biomarkers and in clinical applications for diagnostics. Biosensors based on nucleic acids …

Genetically encoded DNA origami for gene therapy in vivo

X Wu, C Yang, H Wang, X Lu, Y Shang… - Journal of the …, 2023 - ACS Publications
DNA origami has played an important role in various biomedical applications, including
biosensing, bioimaging, and drug delivery. However, the function of the long DNA scaffold …

pH-and miRNA-responsive DNA-tetrahedra/metal–organic framework conjugates: functional sense-and-treat carriers

P Zhang, Y Ouyang, YS Sohn, R Nechushtai… - ACS …, 2021 - ACS Publications
The synthesis of stimuli-responsive hybrid structures composed of drug-loaded UiO-66
metal–organic framework nanoparticles, NMOFs, locked by DNA tetrahedra gates is …

DNA tetrahedra modules as versatile optical sensing platforms for multiplexed analysis of miRNAs, endonucleases, and aptamer–ligand complexes

Z Zhou, YS Sohn, R Nechushtai, I Willner - ACS nano, 2020 - ACS Publications
The sensing modules for analyzing miRNAs or the endonucleases consist of tetrahedra
functionalized with three different fluorophore–quencher pairs in spatially quenched …

Metal‐Modified Nucleic Acids: Metal‐Mediated Base Pairs, Triples, and Tetrads

S Naskar, R Guha, J Mueller - … Chemie International Edition, 2020 - Wiley Online Library
The incorporation of metal ions into nucleic acids by means of metal‐mediated base pairs
represents a promising and prominent strategy for the site‐specific decoration of these self …

Advances in regenerative medicine applications of tetrahedral framework nucleic acid-based nanomaterials: an expert consensus recommendation

Y Lin, Q Li, L Wang, Q Guo, S Liu, S Zhu… - International Journal of …, 2022 - nature.com
With the emergence of DNA nanotechnology in the 1980s, self-assembled DNA
nanostructures have attracted considerable attention worldwide due to their inherent …