Imidazopyridine-based thiazole derivatives as potential antidiabetic agents: synthesis, in vitro bioactivity, and in silico molecular modeling approach
A new series of thiazole derivatives (4a-p) incorporating imidazopyridine moiety was
synthesized and assessed for their in vitro potential α-glucosidase potency using acarbose …
synthesized and assessed for their in vitro potential α-glucosidase potency using acarbose …
Synthesis of novel benzimidazole-based thiazole derivatives as multipotent inhibitors of α-amylase and α-glucosidase: in vitro evaluation along with molecular …
In this study, hybrid analogs of benzimidazole containing a thiazole moiety (1–17) were
afforded and then tested for their ability to inhibit α-amylase and α-glucosidase when …
afforded and then tested for their ability to inhibit α-amylase and α-glucosidase when …
Recent Advances in The Therapeutic Insights of Thiazole Scaffolds as Acetylcholinesterase Inhibitors
DH Dawood, MM Anwar - European Journal of Medicinal Chemistry, 2025 - Elsevier
Suppression of the acetylcholinesterase (AChE) enzyme is a prevalent strategy for curing
diverse mental disorders, including Alzheimer's disease (AD) and the chronic autoimmune …
diverse mental disorders, including Alzheimer's disease (AD) and the chronic autoimmune …
[HTML][HTML] Synthesis, molecular docking study, and biological evaluation and of new thiadiazole and thiazole derivatives incorporating isoindoline-1, 3-dione moiety as …
To highlight the importance of thiazole and thiadiazole derivatives in the progression of
cancer and microbial treatments and to aid in drug design, we have synthesized a new …
cancer and microbial treatments and to aid in drug design, we have synthesized a new …
Multipotent cholinesterase inhibitors for the treatment of Alzheimer's disease: Synthesis, biological analysis and molecular docking study of benzimidazole-based …
Twenty-four analogues of benzimidazole-based thiazoles (1–24) were synthesized and
assessed for their in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) …
assessed for their in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) …
4-Adamantyl-(2-(arylidene) hydrazinyl) thiazoles as potential antidiabetic agents: experimental and docking studies
Aim: To develop an efficient and cost-effective antidiabetic agent. Methods: A simple and
convenient Hantzsch synthetic strategy was used to prepare 4-adamantyl-(2-(arylidene) …
convenient Hantzsch synthetic strategy was used to prepare 4-adamantyl-(2-(arylidene) …
Thieno-Thiazolostilbenes, Thienobenzo-Thiazoles, and Naphtho-Oxazoles: Computational Study and Cholinesterase Inhibitory Activity
Naphtho-triazoles and thienobenzo-triazoles have so far proven to be very potent inhibitors
of the enzyme butyrylcholinesterase (BChE). Based on these results, in this work, new …
of the enzyme butyrylcholinesterase (BChE). Based on these results, in this work, new …
Structural, physicochemical and anticancer study of Zn complexes with pyridyl-based thiazolyl-hydrazones
JB Araškov, N Maciejewska, M Olszewski… - Journal of molecular …, 2023 - Elsevier
Thiazolyl-hydrazones (THs) exhibit a wide spectrum of biological activity that can be
enhanced by complexation with various metal ions. Zn (II) complexes with α-pyridine-1, 3-TH …
enhanced by complexation with various metal ions. Zn (II) complexes with α-pyridine-1, 3-TH …
[HTML][HTML] Synthesis, spectroscopy and biological investigation via DFT, ADMET and molecular docking of Thiadiazole/Oxadiazole based bis-Schiff bases: a potential …
A novel series of varied substituted thiadiazole/oxadiazole based bis-Schiff base derivatives
(1–10) was synthesized and characterized using NMR (13 CNMR and 1 HNMR) and HREI …
(1–10) was synthesized and characterized using NMR (13 CNMR and 1 HNMR) and HREI …
Synthesis of Thiazole‐Chalcone Hybrid Molecules: Antioxidant, Alpha (α)‐Amylase Inhibition and Docking Studies
The molecular hybrid approach is very significant to combat various drug‐resistant
disorders. A simple, convenient, and cost‐effective synthesis of thiazole‐based chalcones is …
disorders. A simple, convenient, and cost‐effective synthesis of thiazole‐based chalcones is …