Cancer remains a significant risk to human health. Nanomedicine is a new multidisciplinary
field that is garnering a lot of interest and investigation. Nanomedicine shows great potential …

Physical forces are ubiquitous in biological processes across scales and diverse contexts.
This review highlights the significance of mechanical forces in nervous system development …

Functional cellular heterogeneity in tumours often underlies incomplete response to therapy
and relapse. Previously, we demonstrated that the growth of the paediatric brain …

Oligodendrocytes are specialized cells that insulate and support axons with their myelin
membrane, allowing proper brain function. Here, we identify lamin A/C (LMNA/C) as …

Mechanosensitive ion channels comprise a broad group of proteins that sense mechanical
extracellular and intracellular changes, translating them into cation influx to adapt and …

Brain tumors represent the leading cause of disease-related mortality and morbidity in
children, with effective treatments urgently required. One factor limiting the effectiveness of …

The pursuit of effective treatments for brain tumors has increasingly focused on the
promising area of nanoparticle-enhanced radiotherapy (NERT). This review elucidates the …

Background The brain is a highly mechanosensitive organ, and changes in the mechanical
properties of brain tissue influence many physiological and pathological processes. Piezo …

Changes in mechanosensitive ion channels following radiation have seldom been linked to
therapeutic sensitivity or specific factors involved in antitumor immunity. Here, in this study …

The DNA damage response (DDR) and the blood-tumor barrier (BTB) restrict
chemotherapeutic success for primary brain tumors like glioblastomas (GBMs). Coherently …