Crohn's disease and ulcerative colitis, phenotypically comprising a spectrum of inflammatory
bowel diseases (IBDs), spread globally during the westernization of lifestyle and dietary …

There is a growing interest in understanding tissue organization, homeostasis, and
inflammation. However, despite an abundance of data, the organizing principles of tissue …

Crohn's disease (CD) is a chronic gastrointestinal disease that is increasing in prevalence
worldwide. CD is multifactorial, involving the complex interplay of genetic, immune, and …

In addition to its canonical function of protection from pathogens, the immune system can
also alter behaviour,. The scope and mechanisms of behavioural modifications by the …

Wound healing requires cooperation between different cell types, among which
macrophages play a central role. In particular, inflammatory macrophages are engaged in …

Tissue resident memory CD8+ T (TRM) cells offer rapid and long-term protection at sites of
reinfection. Tumour-infiltrating lymphocytes with characteristics of TRM cells maintain …

The intestinal epithelium, which segregates the highly stimulatory lumen from the underlying
tissue, harbors one of the largest lymphocyte populations in the body, intestinal …

Omnivorous animals, including mice and humans, tend to prefer energy-dense nutrients rich
in fat over plant-based diets, especially for short periods of time, but the health …

Background The continuous proliferation of intestinal stem cells followed by their tightly
regulated differentiation to epithelial cells is essential for the maintenance of the gut …

Cells in complex organisms undergo frequent functional changes, but few methods allow
comprehensive longitudinal profiling of living cells. Here we introduce scission-accelerated …