Synthetic biology: bottom-up assembly of molecular systems

S Hirschi, TR Ward, WP Meier, DJ Müller… - Chemical …, 2022 - ACS Publications
The bottom-up assembly of biological and chemical components opens exciting
opportunities to engineer artificial vesicular systems for applications with previously unmet …

Microbial rhodopsins: the last two decades

A Rozenberg, K Inoue, H Kandori… - Annual review of …, 2021 - annualreviews.org
Microbial rhodopsins are diverse photoreceptive proteins containing a retinal chromophore
and are found in all domains of cellular life and are even encoded in genomes of viruses …

Optogenetics at the presynapse

BR Rost, J Wietek, O Yizhar, D Schmitz - Nature neuroscience, 2022 - nature.com
Optogenetic actuators enable highly precise spatiotemporal interrogation of biological
processes at levels ranging from the subcellular to cells, circuits and behaving organisms …

Infrared difference spectroscopy of proteins: from bands to bonds

VA Lorenz-Fonfria - Chemical reviews, 2020 - ACS Publications
Infrared difference spectroscopy probes vibrational changes of proteins upon their
perturbation. Compared with other spectroscopic methods, it stands out by its sensitivity to …

A distinct abundant group of microbial rhodopsins discovered using functional metagenomics

A Pushkarev, K Inoue, S Larom, J Flores-Uribe… - Nature, 2018 - nature.com
Many organisms capture or sense sunlight using rhodopsin pigments,, which are integral
membrane proteins that bind retinal chromophores. Rhodopsins comprise two distinct …

Femtosecond-to-millisecond structural changes in a light-driven sodium pump

P Skopintsev, D Ehrenberg, T Weinert, D James… - Nature, 2020 - nature.com
Light-driven sodium pumps actively transport small cations across cellular membranes.
These pumps are used by microorganisms to convert light into membrane potential and …

Illuminating the brain: advances and perspectives in optoelectronics for neural activity monitoring and modulation

S Xu, M Momin, S Ahmed, A Hossain… - Advanced …, 2023 - Wiley Online Library
Optogenetic modulation of brain neural activity that combines optical and electrical modes in
a unitary neural system has recently gained robust momentum. Controlling illumination …

Rhodopsins at a glance

T Nagata, K Inoue - Journal of Cell Science, 2021 - journals.biologists.com
Rhodopsins are photoreceptive membrane proteins consisting of a common heptahelical
transmembrane architecture that contains a retinal chromophore. Rhodopsin was first …

Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels

A Rozenberg, I Kaczmarczyk, D Matzov… - Nature structural & …, 2022 - nature.com
Many organisms sense light using rhodopsins, photoreceptive proteins containing a retinal
chromophore. Here we report the discovery, structure and biophysical characterization of …

Optogenetics: background, methodological advances and potential applications for cardiovascular research and medicine

J Joshi, M Rubart, W Zhu - Frontiers in bioengineering and …, 2020 - frontiersin.org
Optogenetics is an elegant approach of precisely controlling and monitoring the biological
functions of a cell, group of cells, tissues, or organs with high temporal and spatial resolution …