Evaluation of amorphous solid dispersion properties using thermal analysis techniques
JA Baird, LS Taylor - Advanced drug delivery reviews, 2012 - Elsevier
Amorphous solid dispersions are an increasingly important formulation approach to improve
the dissolution rate and apparent solubility of poorly water soluble compounds. Due to their …
the dissolution rate and apparent solubility of poorly water soluble compounds. Due to their …
Hot melt extrusion: Highlighting physicochemical factors to be investigated while designing and optimizing a hot melt extrusion process
Hot-melt extrusion (HME) is a well-accepted and extensively studied method for preparing
numerous types of drug delivery systems and dosage forms. It offers several advantages: no …
numerous types of drug delivery systems and dosage forms. It offers several advantages: no …
Investigation and correlation of drug polymer miscibility and molecular interactions by various approaches for the preparation of amorphous solid dispersions
Curcumin (CUR) was used as a poorly soluble drug whereas polyvinyl pyrrolidone K90
(PVP), Eudragit EPO (EPO), hydroxypropyl methylcellulose E5 (HPMC) and polyethylene …
(PVP), Eudragit EPO (EPO), hydroxypropyl methylcellulose E5 (HPMC) and polyethylene …
[HTML][HTML] Harnessing the therapeutic potential of anticancer drugs through amorphous solid dispersions
The treatment of cancer is still a major challenge. But tremendous progress in anticancer
drug discovery and development has occurred in the last few decades. However, this …
drug discovery and development has occurred in the last few decades. However, this …
Phase transition enthalpy measurements of organic and organometallic compounds and ionic liquids. Sublimation, vaporization, and fusion enthalpies from 1880 to …
W Acree, JS Chickos - Journal of Physical and Chemical Reference …, 2017 - pubs.aip.org
This compendium completes a previous report published in 2016 [2016ACR/CHI] on phase
change enthalpies. Paper I of this compendium includes over 6600 organic compounds …
change enthalpies. Paper I of this compendium includes over 6600 organic compounds …
The effect of ionotropic gelation residence time on alginate cross-linking and properties
The ability to engineer biocompatible polymers with controllable properties is highly
desirable. One such approach is to cross-link carbohydrate polymers using ionotropic …
desirable. One such approach is to cross-link carbohydrate polymers using ionotropic …
Interactions between drugs and polymers influencing hot melt extrusion
Y Li, H Pang, Z Guo, L Lin, Y Dong, G Li… - Journal of Pharmacy …, 2014 - academic.oup.com
Objectives Hot melt extrusion (HME) as a technique for producing amorphous solid
dispersion (ASD) has been widely used in pharmaceutical research. The biggest challenge …
dispersion (ASD) has been widely used in pharmaceutical research. The biggest challenge …
Is a distinctive single Tg a reliable indicator for the homogeneity of amorphous solid dispersion?
For an amorphous drug–polymer solid dispersion, a distinctive single Tg intermediate of the
two Tg values of the two components has been widely considered as an indication of the …
two Tg values of the two components has been widely considered as an indication of the …
Classification of solid dispersions: correlation to (i) stability and solubility (ii) preparation and characterization techniques
Solid dispersion has been a topic of interest in recent years for its potential in improving oral
bioavailability, especially for poorly water soluble drugs where dissolution could be the rate …
bioavailability, especially for poorly water soluble drugs where dissolution could be the rate …
Characterization of amorphous solid dispersions
The study of amorphous solid dispersions (ASDs) is currently one of the most exciting areas
in pharmaceutics. Research has shown that ASDs offer unique advantages in improving the …
in pharmaceutics. Research has shown that ASDs offer unique advantages in improving the …