Heart valves (HVs) are fluidic control components of the heart that ensure unidirectional
blood flow during the cardiac cycle. However, this description does not adequately describe …

Heart valves (HVs) are cardiac structures whose physiological function is to ensure directed
blood flow through the heart over the cardiac cycle. While primarily passive structures that …

A fundamental goal in constitutive modeling is to predict the mechanical behavior of a
material under a generalized loading state. To achieve this goal, rigorous experimentation …

To date, there are no constitutive models for either the natural or bioprosthetic aortic valve
(AV), in part due to experimental complications related to the AV's small size and …

Background—In patients with left ventricular infarction or dilatation, leaflet tethering by
displaced papillary muscles frequently induces mitral regurgitation, which doubles mortality …

Mitral valve competence requires complex interplay between structures that comprise the
mitral apparatus–the mitral annulus, mitral valve leaflets, chordae tendineae, papillary …

Objectives: This study hypothesized that compensatory mitral leaflet area (MLA) adaptation
occurs in patients with persistent atrial fibrillation (AF) without left ventricular (LV) dysfunction …

The native human heart valve leaflet contains a layered microstructure comprising a
hierarchical arrangement of collagen, elastin, proteoglycans and various cell types. Here …

▪ Abstract For native and engineered biological tissues, there exist many physiological,
surgical, and medical device applications where multiaxial material characterization and …

Background—Functional mitral regurgitation (MR) is caused by systolic traction on the mitral
leaflets related to ventricular distortion. Little is known about whether chronic tethering …