The spliceosome is the complex molecular machinery that sequentially assembles on
eukaryotic messenger RNA precursors to remove introns (pre-mRNA splicing), a …

In addition to the ubiquitous loss of the VHL gene in clear cell renal cell carcinoma (ccRCC),
co-deletions of chromatin-regulating genes are common drivers of tumorigenesis …

The Rbfox proteins regulate alternative pre-mRNA splicing by binding to the RNA element
GCAUG. In the nucleus, most of Rbfox is bound to the large assembly of splicing regulators …

Background RNA sequencing (RNA-seq) is increasingly being used as a complementary
tool to DNA sequencing in diagnostics where DNA analysis has been uninformative. RNA …

Abstract Protein arginine methyltransferase 9 (PRMT9) is a recently identified member of the
PRMT family, yet its biological function remains largely unknown. Here, by characterizing an …

Manipulating gene expression is crucial for understanding gene function, with high-
throughput sequencing techniques such as RNA-seq elucidating the downstream …

Alternative splicing (AS) is emerging as an important regulatory process for complex
biological processes. Transcriptomic studies therefore commonly involve the identification …

Myotonic dystrophy type 1 (DM1), the leading cause of adult-onset muscular dystrophy, is
caused by a CTG repeat expansion. Expression of the repeat causes widespread alternative …

Aberrant RNA alternative splicing in cancer generates varied novel isoforms and protein
variants that facilitate cancer progression. Here, we employed the advanced long-read full …

Background In bivalves, the rate at which organisms grow is a major functional trait
underlying many aspects of their commercial production. Growth is a highly polygenic trait …