Genetic abnormalities in the DNA repair genes BRCA1 and BRCA2 predispose to hereditary
breast and ovarian cancer (HBOC). However, only approximately 25% of cases of HBOC …

The use of multigene panels for the assessment of cancer susceptibility is expanding rapidly
in clinical practice, particularly in the USA, despite concerns regarding the uncertain clinical …

Background Population-based estimates of the risk of breast cancer associated with
germline pathogenic variants in cancer-predisposition genes are critically needed for risk …

Gene-Panel Sequencing and the Prediction of Breast-Cancer Risk | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

The sixth generation (6G) wireless communication network presents itself as a promising
technique that can be utilized to provide a fully data-driven network evaluating and …

Breast and ovarian cancers are some of the most common tumors in females, and the
genetic predisposition is emerging as one of the key risk factors in the development of these …

Background BRCA1 interacting protein C-terminal helicase 1 (BRIP1) is one of the Fanconi
Anaemia Complementation (FANC) group family of DNA repair proteins. Biallelic mutations …

Pathogenic variants in BRCA1 and BRCA2 only explain the underlying genetic cause of
about 10% of hereditary breast and ovarian cancer families. Because of cost‐effectiveness …

Sequencing tests assaying panels of genes or whole exomes are widely available for
cancer risk evaluation. However, methods for classification of variants resulting from this …

PURPOSE The prevalence of germline pathogenic variants (PVs) in established breast
cancer predisposition genes in women in the general population over age 65 years is not …