Metastasis involves the spread of cancer cells from the primary tumor to surrounding tissues
and to distant organs and is the primary cause of cancer morbidity and mortality. In order to …

The causes of metastasis remain elusive despite vast information on cancer cells. We posit
that cancer cell fusion with macrophages or other migratory bone marrow-derived cells …

The cause of metastasis remains elusive despite vast information on cancer cells. We posit
that cancer cell fusion with macrophages or other migratory bone marrow‐derived cells …

Cell fusion is a physiological cellular process essential for fertilization, viral entry, muscle
differentiation and placental development, among others. In this review, we will highlight the …

Malignant cells express molecular pathways that are also expressed by myeloid cells. Such
behaviour is associated with loss of homotypic adhesion between cells, changes in the …

Tumor‐associated macrophages (TAMs) represent a distinct malignancy‐promoting
phenotype suggested to play a key role in tumor formation and metastasis. We aimed to …

Background Tumor cell fusion with motile bone marrow-derived cells (BMDCs) has long
been posited as a mechanism for cancer metastasis. While there is much support for this …

Macrophages are a heterogeneous cell population of the myeloid linage derived from
monocytes. These cells show two different polarization states, M1 and M2 macrophages in …

When the body discovers a tumour cell (foreign antigen), several kinds of mechanisms and
cells operate in what is called an immune response. The latter has evolved into two …

Breast cancer progression involves cancer cell heterogeneity, with generation of
invasive/metastatic breast cancer cells within populations of nonmetastatic cells of the …