Ovarian reserve is essential for fertility and influences healthy aging in women. Advanced
maternal age correlates with the progressive loss of both the quantity and quality of oocytes …

After fertilization, sperm and oocyte fused and gave rise to a zygote which is the beginning of
a new life. Then the embryonic development is monitored and regulated precisely from the …

Abnormal resumption of meiosis and decreased oocyte quality are hallmarks of maternal
aging. Transcriptional silencing makes translational control an urgent task during meiosis …

Aging-associated histone modification changes in oocytes have been sporadically reported,
but the underlying mechanisms remain elusive. Here, we systematically characterize …

Female infertility due to declining oocyte quality with age remains a significant challenge for
patients and physicians, despite extensive research efforts. Recent studies suggest that …

The yak (Bos grunniens) is a unique breed living on the Qinghai–Tibet Plateau and its
surrounding areas, providing locals with a variety of vital means of living and production …

The female reproductive axis is one of the first organ systems to age, which has
consequences for fertility and overall health. Here, we provide a comprehensive overview of …

The developmental competence and epigenetic progression of oocytes gradually become
dysregulated with increasing maternal age. However, the mechanisms underlying age …

Age-related aneuploidy in human oocytes is a major factor contributing to decreased fertility
and adverse reproductive outcomes. As females age, their oocytes are more prone to …

The versatile epigenetic modification known as N6‐methyladenosine (m6A) has been
demonstrated to be pivotal in numerous physiological and pathological contexts …