Ion channels and channelopathies in glomeruli
An essential step in renal function entails the formation of an ultrafiltrate that is delivered to
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …
[HTML][HTML] The mammalian TRPC cation channels
Transient Receptor Potential-Canonical (TRPC) channels are mammalian homologs of
Transient Receptor Potential (TRP), a Ca2+-permeable channel involved in the …
Transient Receptor Potential (TRP), a Ca2+-permeable channel involved in the …
Local Ca2+ Entry Via Orai1 Regulates Plasma Membrane Recruitment of TRPC1 and Controls Cytosolic Ca2+ Signals Required for Specific Cell Functions
KT Cheng, X Liu, HL Ong, W Swaim, IS Ambudkar - PLoS biology, 2011 - journals.plos.org
Store-operated Ca2+ entry (SOCE) has been associated with two types of channels: CRAC
channels that require Orai1 and STIM1 and SOC channels that involve TRPC1, Orai1, and …
channels that require Orai1 and STIM1 and SOC channels that involve TRPC1, Orai1, and …
Structural basis of TRPC4 regulation by calmodulin and pharmacological agents
D Vinayagam, D Quentin, J Yu-Strzelczyk, O Sitsel… - Elife, 2020 - elifesciences.org
Canonical transient receptor potential channels (TRPC) are involved in receptor-operated
and/or store-operated Ca2+ signaling. Inhibition of TRPCs by small molecules was shown to …
and/or store-operated Ca2+ signaling. Inhibition of TRPCs by small molecules was shown to …
TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology
Loss or dysfunction of podocytes is a major cause of glomerular kidney disease. Several
genetic forms of glomerular disease are caused by mutations in genes that encode structural …
genetic forms of glomerular disease are caused by mutations in genes that encode structural …
TRPC channels as STIM1-regulated store-operated channels
Receptor-activated Ca2+ influx is mediated largely by store-operated channels (SOCs).
TRPC channels mediate a significant portion of the receptor-activated Ca2+ influx. However …
TRPC channels mediate a significant portion of the receptor-activated Ca2+ influx. However …
Non‐selective cationic channels of smooth muscle and the mammalian homologues of Drosophila TRP
DJ Beech, K Muraki, R Flemming - The Journal of physiology, 2004 - Wiley Online Library
Throughout the body there are smooth muscle cells controlling a myriad of tubes and
reservoirs. The cells show enormous diversity and complexity compounded by a plasticity …
reservoirs. The cells show enormous diversity and complexity compounded by a plasticity …
Regulation of superoxide production in neutrophils: role of calcium influx
S Bréchard, EJ Tschirhart - Journal of Leucocyte Biology, 2008 - academic.oup.com
Upon stimulation, activation of NADPH oxidase complexes in neutrophils produces a burst
of superoxide anions contributing to oxidative stress and the development of inflammatory …
of superoxide anions contributing to oxidative stress and the development of inflammatory …
Multiple roles of calmodulin and other Ca2+-binding proteins in the functional regulation of TRP channels
MX Zhu - Pflügers Archiv, 2005 - Springer
Transient receptor potential channels (TRP) have emerged as cellular sensors of various
internal and external cues. Generally, the activation of TRP canonical (TRPC) channels is …
internal and external cues. Generally, the activation of TRP canonical (TRPC) channels is …
Development of store-operated calcium entry-targeted compounds in cancer
X Liang, N Zhang, H Pan, J **e, W Han - Frontiers in Pharmacology, 2021 - frontiersin.org
Store-operated Ca2+ entry (SOCE) is the major pathway of Ca2+ entry in mammalian cells,
and regulates a variety of cellular functions including proliferation, motility, apoptosis, and …
and regulates a variety of cellular functions including proliferation, motility, apoptosis, and …