Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases

SC Liew, ED Gupta - European journal of medical genetics, 2015 - Elsevier
Abstract The Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is
associated with various diseases (vascular, cancers, neurology, diabetes, psoriasis, etc) …

Breast cancer in Arab populations: molecular characteristics and disease management implications

L Chouchane, H Boussen, KSR Sastry - The lancet oncology, 2013 - thelancet.com
Breast cancer is a major health problem in both develo** and developed countries. It is
the most frequently diagnosed female malignant disease in Arab populations. The incidence …

MTHFR C677T polymorphism and breast, ovarian cancer risk: a meta-analysis of 19,260 patients and 26,364 controls

L He, Y Shen - OncoTargets and therapy, 2017 - Taylor & Francis
Objective Previous studies have found that many gene variations can be detected in both
breast cancer and ovarian cancer, which is beneficial for the elaboration of the molecular …

[HTML][HTML] Methylenetetrahydrofolate reductase gene C677T polymorphism and breast cancer risk: Evidence for genetic susceptibility

P Kumar, U Yadav, V Rai - Meta Gene, 2015 - Elsevier
There are several evidences supporting the role of 5–10 methylenetetrahydrofolate
reductase (MTHFR) gene polymorphisms in breast cancer (BC). Case control association …

Arab gene geography: From population diversities to personalized medical genomics

GO Tadmouri, KS Sastry, L Chouchane - Global Cardiology Science …, 2015 - qscience.com
Genetic disorders are not equally distributed over the geography of the Arab region. While a
number of disorders have a wide geographical presence encompassing 10 or more Arab …

Association of MTRR A66G polymorphism with cancer susceptibility: Evidence from 85 studies

P Wang, S Li, M Wang, J He, S ** - Journal of cancer, 2017 - pmc.ncbi.nlm.nih.gov
Methionine synthase reductase (MTRR) is a key regulatory enzyme involved in the folate
metabolic pathway. Previous studies investigating the association of MTRR A66G …

Genetic profile and determinants of homocysteine levels in Kazakhstan patients with breast cancer

A Akilzhanova, Z Nurkina, K Momynaliev… - Anticancer …, 2013 - ar.iiarjournals.org
Aim: To analyze associations between homocysteine level, MTHFR and FTO rs1477196
polymorphisms and folate status in patients with breast cancer (BC) in order to clarify …

Association of MHTFR Ala222Val (rs1801133) polymorphism and breast cancer susceptibility: An update meta-analysis based on 51 research studies

L Yu, J Chen - Diagnostic pathology, 2012 - Springer
Background The association between MHTFR Ala222Val polymorphism and breast cancer
(BC) risk are inconclusive. To derive a more precise estimation of the relationship, a …

Breast cancer risk associated with gene expression and genotype polymorphisms of the folate-metabolizing MTHFR gene: a case-control study in a high altitude …

A López-Cortés, C Echeverría, F Oña-Cisneros… - Tumor Biology, 2015 - Springer
Breast cancer (BC) is the leading cause of cancer-related death among women in 2014.
Methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and MTR …

Association of 677 C>T (rs1801133) and 1298 A>C (rs1801131) Polymorphisms in the MTHFR Gene and Breast Cancer Susceptibility: A Meta-Analysis Based on …

K Li, W Li, X Dong - PloS one, 2014 - journals.plos.org
Objective The 677 C> T and 1298 A> C polymorphisms of methylenetetrahydrofolate
reductase (MTHFR) gene have been widely reported and considered to have a significant …