After the hurricane: Anti-COVID-19 drugs development, molecular mechanisms of action and future perspectives
HO Khalifa, YM Al Ramahi - International Journal of Molecular Sciences, 2024 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a new coronavirus in
the Coronaviridae family. The COVID-19 pandemic, caused by SARS-CoV-2, has …
the Coronaviridae family. The COVID-19 pandemic, caused by SARS-CoV-2, has …
Integrating Artificial Intelligence for Drug Discovery in the Context of Revolutionizing Drug Delivery
Drug development is expensive, time-consuming, and has a high failure rate. In recent
years, artificial intelligence (AI) has emerged as a transformative tool in drug discovery …
years, artificial intelligence (AI) has emerged as a transformative tool in drug discovery …
Unveiling the potential of phytochemicals to inhibit nuclear receptor binding SET domain protein 2 for cancer: Pharmacophore screening, molecular docking, ADME …
Nuclear receptor binding SET domain protein 2 (NSD2) significantly contributes to the
development of cancer, making it a promising target for cancer drug discovery. This research …
development of cancer, making it a promising target for cancer drug discovery. This research …
Targeting the omicron variant of SARS-CoV-2 with phytochemicals from Saudi medicinal plants: Molecular docking combined with molecular dynamics investigations
L Eltaib, AA Alzain - Journal of Biomolecular Structure and …, 2023 - Taylor & Francis
The new health crises caused by SARS-CoV-2 have resulted in millions of deaths
worldwide. First discovered in November 2021, the omicron variant is more transmissible …
worldwide. First discovered in November 2021, the omicron variant is more transmissible …
[HTML][HTML] Identification of novel Plasmodium falciparum dihydroorotate dehydrogenase inhibitors for malaria using in silico studies
AA Alzain, ZAM Ahmed, MA Mahadi, FA Elbadwi - Scientific African, 2022 - Elsevier
Malaria, that ancient infectious disease is considered a great health problem due to its
highly infectious and mortality rates. The more harmful kind of malaria is Plasmodium …
highly infectious and mortality rates. The more harmful kind of malaria is Plasmodium …
Integrating computational methods guided the discovery of phytochemicals as potential Pin1 inhibitors for cancer: pharmacophore modeling, molecular docking, MM …
AA Alzain, FA Elbadwi, TH Shoaib, AE Sherif… - Frontiers in …, 2024 - frontiersin.org
Pin1 is a pivotal player in interactions with a diverse array of phosphorylated proteins closely
linked to critical processes such as carcinogenesis and tumor suppression. Its axial role in …
linked to critical processes such as carcinogenesis and tumor suppression. Its axial role in …
In Silico Models for Anti‐COVID‐19 Drug Discovery: A Systematic Review
OH Onyango - Advances in pharmacological and …, 2023 - Wiley Online Library
The coronavirus disease 2019 (COVID‐19) is a severe worldwide pandemic. Due to the
emergence of various SARS‐CoV‐2 variants and the presence of only one Food and Drug …
emergence of various SARS‐CoV‐2 variants and the presence of only one Food and Drug …
Repurposing immune boosting and anti-viral efficacy of Parkia bioactive entities as multi-target directed therapeutic approach for SARS-CoV-2: exploration of lead …
The COVID-19 pandemic has caused adverse health (severe respiratory, enteric and
systemic infections) and environmental impacts that have threatened public health and the …
systemic infections) and environmental impacts that have threatened public health and the …
Turning down PI3K/AKT/mTOR signalling pathway by natural products: an in silico multi-target approach
N Abd Emoniem, RM Mukhtar… - SAR and QSAR in …, 2023 - Taylor & Francis
ABSTRACT The PI3K/AKT/mTOR pathway is a significant target for cancer drug discovery.
Many efforts have focused on discovering new inhibitors against key kinase proteins …
Many efforts have focused on discovering new inhibitors against key kinase proteins …
The SARS-CoV-2 antibodies, their diagnostic utility, and their potential for vaccine development
Antibodies (Abs) are important immune mediators and powerful diagnostic markers in a
wide range of infectious diseases. Understanding the humoral immunity or the development …
wide range of infectious diseases. Understanding the humoral immunity or the development …