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Application of exosomes as liquid biopsy in clinical diagnosis
B Zhou, K Xu, X Zheng, T Chen, J Wang… - Signal transduction and …, 2020 - nature.com
Liquid biopsy refers to the sampling and molecular analysis of the biofluids of circulating
tumor cells, extracellular vesicles, nucleic acids, and so forth. Exosomes are small …
tumor cells, extracellular vesicles, nucleic acids, and so forth. Exosomes are small …
MicroRNAs as therapeutic targets in cardiovascular disease
B Laggerbauer, S Engelhardt - The Journal of clinical investigation, 2022 - jci.org
The discovery of microRNAs and their role in diseases was a breakthrough that inspired
research into microRNAs as drug targets. Cardiovascular diseases are an area in which …
research into microRNAs as drug targets. Cardiovascular diseases are an area in which …
[HTML][HTML] Cardiomyopathies: an overview
T Ciarambino, G Menna, G Sansone… - International journal of …, 2021 - mdpi.com
Background: Cardiomyopathies are a heterogeneous group of pathologies characterized by
structural and functional alterations of the heart. Aims: The purpose of this narrative review is …
structural and functional alterations of the heart. Aims: The purpose of this narrative review is …
Pathophysiology, diagnosis and management of peripartum cardiomyopathy: a position statement from the Heart Failure Association of the European Society of …
Peripartum cardiomyopathy (PPCM) is a potentially life‐threatening condition typically
presenting as heart failure with reduced ejection fraction (HFrEF) in the last month of …
presenting as heart failure with reduced ejection fraction (HFrEF) in the last month of …
Therapeutic and diagnostic translation of extracellular vesicles in cardiovascular diseases: roadmap to the clinic
Exosomes are small membrane-bound vesicles of endocytic origin that are actively
secreted. The potential of exosomes as effective communicators of biological signaling in …
secreted. The potential of exosomes as effective communicators of biological signaling in …
Exosomes: new molecular targets of diseases
Extracellular vesicles (EVs) comprise apoptotic bodies, microvesicles and exosomes, and
they perform as key regulators in cell-to-cell communication in normal as well as diseased …
they perform as key regulators in cell-to-cell communication in normal as well as diseased …
MicroRNA in cardiovascular biology and disease.
A Wojciechowska, A Braniewska… - … in Clinical & …, 2017 - search.ebscohost.com
MicroRNAs (miRNAs) are members of a non-coding RNA family. They act as negative
regulators of protein translation by affecting messenger RNA (mRNA) stability; they …
regulators of protein translation by affecting messenger RNA (mRNA) stability; they …
[HTML][HTML] Methodologies to isolate and purify clinical grade extracellular vesicles for medical applications
The use of extracellular vesicles (EV) in nano drug delivery has been demonstrated in many
previous studies. In this study, we discuss the sources of extracellular vesicles, including …
previous studies. In this study, we discuss the sources of extracellular vesicles, including …
Shared genetic predisposition in peripartum and dilated cardiomyopathies
JS Ware, J Li, E Mazaika, CM Yasso… - … England Journal of …, 2016 - Mass Medical Soc
Background Peripartum cardiomyopathy shares some clinical features with idiopathic
dilated cardiomyopathy, a disorder caused by mutations in more than 40 genes, including …
dilated cardiomyopathy, a disorder caused by mutations in more than 40 genes, including …
Cardiac fibroblast–derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy
In response to stress, the heart undergoes extensive cardiac remodeling that results in
cardiac fibrosis and pathological growth of cardiomyocytes (hypertrophy), which contribute …
cardiac fibrosis and pathological growth of cardiomyocytes (hypertrophy), which contribute …