Application of exosomes as liquid biopsy in clinical diagnosis

B Zhou, K Xu, X Zheng, T Chen, J Wang… - Signal transduction and …, 2020 - nature.com
Liquid biopsy refers to the sampling and molecular analysis of the biofluids of circulating
tumor cells, extracellular vesicles, nucleic acids, and so forth. Exosomes are small …

MicroRNAs as therapeutic targets in cardiovascular disease

B Laggerbauer, S Engelhardt - The Journal of clinical investigation, 2022 - jci.org
The discovery of microRNAs and their role in diseases was a breakthrough that inspired
research into microRNAs as drug targets. Cardiovascular diseases are an area in which …

[HTML][HTML] Cardiomyopathies: an overview

T Ciarambino, G Menna, G Sansone… - International journal of …, 2021 - mdpi.com
Background: Cardiomyopathies are a heterogeneous group of pathologies characterized by
structural and functional alterations of the heart. Aims: The purpose of this narrative review is …

Pathophysiology, diagnosis and management of peripartum cardiomyopathy: a position statement from the Heart Failure Association of the European Society of …

J Bauersachs, T König, P van der Meer… - European journal of …, 2019 - Wiley Online Library
Peripartum cardiomyopathy (PPCM) is a potentially life‐threatening condition typically
presenting as heart failure with reduced ejection fraction (HFrEF) in the last month of …

Therapeutic and diagnostic translation of extracellular vesicles in cardiovascular diseases: roadmap to the clinic

S Sahoo, M Adamiak, P Mathiyalagan, F Kenneweg… - Circulation, 2021 - ahajournals.org
Exosomes are small membrane-bound vesicles of endocytic origin that are actively
secreted. The potential of exosomes as effective communicators of biological signaling in …

Exosomes: new molecular targets of diseases

S Samanta, S Rajasingh, N Drosos, Z Zhou… - Acta Pharmacologica …, 2018 - nature.com
Extracellular vesicles (EVs) comprise apoptotic bodies, microvesicles and exosomes, and
they perform as key regulators in cell-to-cell communication in normal as well as diseased …

MicroRNA in cardiovascular biology and disease.

A Wojciechowska, A Braniewska… - … in Clinical & …, 2017 - search.ebscohost.com
MicroRNAs (miRNAs) are members of a non-coding RNA family. They act as negative
regulators of protein translation by affecting messenger RNA (mRNA) stability; they …

[HTML][HTML] Methodologies to isolate and purify clinical grade extracellular vesicles for medical applications

A Akbar, F Malekian, N Baghban, SP Kodam, M Ullah - Cells, 2022 - mdpi.com
The use of extracellular vesicles (EV) in nano drug delivery has been demonstrated in many
previous studies. In this study, we discuss the sources of extracellular vesicles, including …

Shared genetic predisposition in peripartum and dilated cardiomyopathies

JS Ware, J Li, E Mazaika, CM Yasso… - … England Journal of …, 2016 - Mass Medical Soc
Background Peripartum cardiomyopathy shares some clinical features with idiopathic
dilated cardiomyopathy, a disorder caused by mutations in more than 40 genes, including …

Cardiac fibroblast–derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy

C Bang, S Batkai, S Dangwal, SK Gupta… - The Journal of clinical …, 2014 - jci.org
In response to stress, the heart undergoes extensive cardiac remodeling that results in
cardiac fibrosis and pathological growth of cardiomyocytes (hypertrophy), which contribute …