Acrylic bone cement has considerable laboratory and clinical data validating it as a delivery
material for depot administration of antibiotics. However, an alternate material that does not …

Bacterial contamination of implanted orthopedic prostheses is a serious complication that
requires prolonged systemic antibiotic therapy, major surgery to remove infected implants …

An important limitation in the development of biodegradable polymer microspheres for
controlled-release drug delivery applications has been the difficulty of specifically designing …

The aim of this study was an in vitro/in vivo investigation on poly (lactide-co-
glycolide)(PLGA) microspheres as carriers for the topical ocular delivery of a peptide drug …

The biodegradable chitosan microspheres containing vancomycin hydrochloride (VANCO)
were prepared by spray drying method with different polymer: drug ratios (1: 1, 2: 1, 3: 1 and …

Implant-associated infections are not easy to diagnose and very difficult to treat, due to the
ability of major pathogens, such as Staphylococcus aureus, to develop biofilms and escape …

Polymeric microparticles have been used widely for sustained drug delivery. Current
methods of microparticle production can be improved by making homogeneous particles in …

In this paper, microencapsulation based on emulsification coupling with solvent evaporation,
ionotropic gelation, coacervation technique, and spray drying are critically reviewed. The …

Purpose This study investigated the effects of the physicochemical properties of antibiotics
on the morphology, loading efficiency, size, release kinetics, and antibiotic efficacy of loaded …

Autologous platelet-rich fibrin (PRF) is derived from the blood and its use in the bone tissue
engineering has emerged as an effective strategy for novel drug and growth factor delivery …