Targeting senescent cells in translational medicine
M Paez‐Ribes, E González‐Gualda… - EMBO molecular …, 2019 - embopress.org
Organismal ageing is a complex process driving progressive impairment of functionality and
regenerative potential of tissues. Cellular senescence is a state of stable cell cycle arrest …
regenerative potential of tissues. Cellular senescence is a state of stable cell cycle arrest …
Cellular senescence: molecular targets, biomarkers, and senolytic drugs
Cellular senescence is defined as irreversible cell cycle arrest caused by various processes
that render viable cells non-functional, hampering normal tissue homeostasis. It has many …
that render viable cells non-functional, hampering normal tissue homeostasis. It has many …
Apoptosis and its therapeutic implications in neurodegenerative diseases
NS Erekat - Clinical Anatomy, 2022 - Wiley Online Library
Neurodegenerative disorders are characterized by progressive loss of particular populations
of neurons. Apoptosis has been implicated in the pathogenesis of neurodegenerative …
of neurons. Apoptosis has been implicated in the pathogenesis of neurodegenerative …
Bax/Bcl-2 cascade is regulated by the EGFR pathway: therapeutic targeting of non-small cell lung cancer
Non-small cell lung carcinoma (NSCLC) comprises 80%–85% of lung cancer cases. EGFR
is involved in several cancer developments, including NSCLC. The EGFR pathway …
is involved in several cancer developments, including NSCLC. The EGFR pathway …
Inhibition of anti-apoptotic Bcl-2 proteins in preclinical and clinical studies: current overview in cancer
S D'Aguanno, D Del Bufalo - Cells, 2020 - mdpi.com
The dynamic interplay between pro-death and pro-survival Bcl-2 family proteins is
responsible for a cell's fate. Due to the recognized relevance of this family in cancer …
responsible for a cell's fate. Due to the recognized relevance of this family in cancer …
[HTML][HTML] Therapeutic interventions for aging: the case of cellular senescence
A Soto-Gamez, M Demaria - Drug Discovery Today, 2017 - Elsevier
Highlights•Senescent cells contribute to aging and age-related diseases.•Reducing the
secretory phenotype of senescent cells (SASP) has beneficial effects.•Elimination of …
secretory phenotype of senescent cells (SASP) has beneficial effects.•Elimination of …
B cell lymphoma 2: a potential therapeutic target for cancer therapy
Defects in the apoptosis mechanism stimulate cancer cell growth and survival. B cell
lymphoma 2 (Bcl-2) is an anti-apoptotic molecule that plays a central role in apoptosis. Bcl-2 …
lymphoma 2 (Bcl-2) is an anti-apoptotic molecule that plays a central role in apoptosis. Bcl-2 …
Emerging therapeutic approaches to target the dark side of senescent cells: new hopes to treat aging as a disease and to delay age-related pathologies
R Khalil, M Diab-Assaf, JM Lemaitre - Cells, 2023 - mdpi.com
Life expectancy has drastically increased over the last few decades worldwide, with
important social and medical burdens and costs. To stay healthy longer and to avoid chronic …
important social and medical burdens and costs. To stay healthy longer and to avoid chronic …
Crosstalk between endoplasmic reticulum stress and oxidative stress: a dynamic duo in multiple myeloma
S ** global
concern, cancer determent is one of the most significant public health challenges of this era …
concern, cancer determent is one of the most significant public health challenges of this era …