Memory engrams: Recalling the past and imagining the future

SA Josselyn, S Tonegawa - Science, 2020 - science.org
BACKGROUND The idea that memory is stored as enduring changes in the brain dates
back at least to the time of Plato and Aristotle (circa 350 BCE), but its scientific articulation …

A contextual binding theory of episodic memory: systems consolidation reconsidered

AP Yonelinas, C Ranganath, AD Ekstrom… - Nature Reviews …, 2019 - nature.com
Episodic memory reflects the ability to recollect the temporal and spatial context of past
experiences. Episodic memories depend on the hippocampus but have been proposed to …

[LIBRO][B] Il cervello emotivo: alle origini delle emozioni

JE LeDoux, S Coyaud - 2003 - humanamente.eu
Da William James a Damasio, LeDoux ripropone la storia di uno dei percorsi più importanti
delle neuroscienze. Attraverso l'analisi di oltre cento anni di studi sulle emozioni, in questo …

Neocortical synaptic engrams for remote contextual memories

JH Lee, WB Kim, EH Park, JH Cho - Nature Neuroscience, 2023 - nature.com
While initial encoding of contextual memories involves the strengthening of hippocampal
circuits, these memories progressively mature to stabilized forms in neocortex and become …

All-optical physiology resolves a synaptic basis for behavioral timescale plasticity

LZ Fan, DK Kim, JH Jennings, H Tian, PY Wang… - Cell, 2023 - cell.com
Learning has been associated with modifications of synaptic and circuit properties, but the
precise changes storing information in mammals have remained largely unclear. We …

Engrams and circuits crucial for systems consolidation of a memory

T Kitamura, SK Ogawa, DS Roy, T Okuyama… - Science, 2017 - science.org
Episodic memories initially require rapid synaptic plasticity within the hippocampus for their
formation and are gradually consolidated in neocortical networks for permanent storage …

The hippocampal sharp wave–ripple in memory retrieval for immediate use and consolidation

HR Joo, LM Frank - Nature Reviews Neuroscience, 2018 - nature.com
Various cognitive functions have long been known to require the hippocampus. Recently,
progress has been made in identifying the hippocampal neural activity patterns that …

The role of engram cells in the systems consolidation of memory

S Tonegawa, MD Morrissey, T Kitamura - Nature Reviews …, 2018 - nature.com
What happens to memories as days, weeks and years go by has long been a fundamental
question in neuroscience and psychology. For decades, researchers have attempted to …

Neurocognitive effects of stress: a metaparadigm perspective

EJ Kim, JJ Kim - Molecular Psychiatry, 2023 - nature.com
Stressful experiences, both physical and psychological, that are overwhelming (ie,
inescapable and unpredictable), can measurably affect subsequent neuronal properties and …

Brain region–specific action of ketamine as a rapid antidepressant

M Chen, S Ma, H Liu, Y Dong, J Tang, Z Ni, Y Tan… - Science, 2024 - science.org
Ketamine has been found to have rapid and potent antidepressant activity. However, despite
the ubiquitous brain expression of its molecular target, the N-methyl-d-aspartate receptor …