Magnetic resonance imaging (MRI) has become one of the most widely used and powerful
tools for noninvasive clinical diagnosis owing to its high degree of soft tissue contrast, spatial …

Vascular cell adhesion molecule-1 (VCAM-1) has been well established as a critical
contributor to atherosclerosis and consequently as an attractive therapeutic target for anti …

Dynamic remodeling of the extracellular matrix (ECM) is essential for development, wound
healing and normal organ homeostasis. Life-threatening pathological conditions arise when …

Advances in atherosclerosis imaging technology and research have provided a range of
diagnostic tools to characterize high-risk plaque in vivo; however, these important vascular …

Injection of recombinant tissue plasminogen activator (rt-PA) is the standard drug treatment
for thrombolysis. However, rt-PA shows risk of hemorrhages and limited efficiency even at …

A long-standing goal of nanomedicine is to improve a drug's benefit by loading it into a
nanocarrier that homes solely to a specific target cell and organ. Unfortunately, nanocarriers …

The bloodstream is the main transporting pathway for drug delivery systems (DDS) from the
site of administration to the intended site of action. In many cases, components of the …

Targeted nanomedicine holds promise to find clinical use in many medical areas.
Endothelial cells that line the luminal surface of blood vessels represent a key target for …

Collagens constitute a major portion of the extracellular matrix in the atherosclerotic plaque,
where they contribute to the strength and integrity of the fibrous cap, and also modulate …

Inflammation is a key factor in multiple diseases including primary immune-mediated
inflammatory diseases eg rheumatoid arthritis but also, less obviously, in many other …