Atopic dermatitis (AD) is a chronic, allergic inflammatory skin disorder that lacks a definite
cure. Using a mouse DNCB-induced AD-like skin lesions model, this study evaluated the …

Lipoxygenase (5-LO) is one of the key enzymes involved in the production of pro-
inflammatory mediators, such as leukotriene B4 and cysteinyl leukotrienes. Inhibition of 5-LO …

We previously demonstrated the alleviation of ovalbumin (OVA)-induced airway
inflammation by Inulae flos. In the present study, the effects of britanin, a sesquiterpene …

Abstract tHGA, a geranyl acetophenone compound originally isolated from a local shrub
called Melicope ptelefolia, has been previously reported to prevent ovalbumin-induced …

Alveolar epithelial barrier dysfunction contributes to lung edema and can lead to acute lung
injury (ALI). The features include increased epithelial permeability, upregulation of …

The natural product molecule 2, 4, 6-trihydroxy-3-geranyl-acetophenone (tHGA) isolated
from the medicinal plant Melicope ptel efolia was shown to exhibit potent lipoxygenase …

Epithelial-mesenchymal transition (EMT) is currently recognized as the main cellular event
that contributes to airway remodeling. Eosinophils can induce EMT in airway epithelial cells …

Abstract 2, 4, 6-Trihydroxy-3-geranyl acetophenone (tHGA) is a synthetic compound that is
naturally found in Melicope ptelefolia. We had previously demonstrated that parenteral …

A new series of 2, 4, 6-trihydroxy-3-geranyl-acetophenone (tHGA) analogues were
synthesized and evaluated for their lipoxygenase (LOX) inhibitory activity. Prenylated …

Mast cells play a central role in the pathogenesis of allergic reaction. Activation of mast cells
by antigens is strictly dependent on the influx of extracellular calcium that involves a …