Hydrogel is a type of versatile platform with various biomedical applications after rational
structure and functional design that leverages on material engineering to modulate its …

Tissue engineering often uses synthetic scaffolds to direct cell responses during engineered
tissue development. Since cells reside within specific niches of the extracellular matrix, it is …

Engineering synthetic scaffolds to repair and regenerate ruptured native tendon and
ligament (T/L) tissues is a significant engineering challenge due to the need to satisfy both …

Scars caused by skin injuries after burns, wounds, abrasions and operations have serious
physical and psychological effects on patients. In recent years, the research of scar free …

Delayed injured nerve regeneration remains a clinical problem, partly ascribing to the lack of
regulation of regenerative microenvironment, topographical cues, and blood nourishment …

Adult tendon tissue demonstrates a limited regenerative capacity, and the natural repair
process leaves fibrotic scar tissue with inferior mechanical properties. Surgical treatment is …

Decellularized tissues are a valid alternative as tissue engineering scaffolds, thanks to the
three-dimensional structure that mimics native tissues to be regenerated and the biomimetic …

Appropriate macrophage response to an implanted biomaterial is crucial for successful
tissue healing outcomes. In this work we investigated how intrinsic topological cues from …

Musculoskeletal disorders are common in clinical practice. Repairing critical-sized defects in
musculoskeletal systems remains a challenge for researchers and surgeons, requiring the …

Replicating the controlled nanofibrillar architecture of collagenous tissue represents a
promising approach in the design of tendon replacements that have tissue-mimicking …