The pathophysiology of Parkinson's disease (PD) tremor remains incompletely understood
and there is a lack of clinical trials specifically addressing its pharmacological treatment …

The degeneration of mesencephalic dopaminergic neurons that innervate the basal ganglia
is responsible for the cardinal motor symptoms of Parkinson's disease (PD). It has been …

Genes associated with risk for brain disease exhibit characteristic expression patterns that
reflect both anatomical and cell type relationships. Brain-wide transcriptomic patterns of …

Striatal activity is dynamically modulated by acetylcholine and dopamine, both of which are
essential for basal ganglia function. Synchronized pauses in the activity of striatal …

Neurotransmitters are considered as a fundamental regulator in the process of neuronal
growth, differentiation and survival. Parkinson's Disease (PD) occurs due to extensive …

Parkinson's disease is the most common movement disorder, affecting about 1% of the
population over the age of 60 years. Parkinson's disease is characterized clinically by …

Movement, behavioral, and neuropsychiatric disorders in children have been linked to
infections and a group of anti-neuronal autoantibodies, implying dopamine receptor …

Detecting physiological levels of neurotransmitters in biological samples can advance our
understanding of brain disorders and lead to improved diagnostics and therapeutics …

Cholinergic signaling is crucial in cognitive processes, and degenerating cholinergic
projections are a pathological hallmark in dementia. Use of cholinesterase inhibitors is …

One of the major environmental factors that induce PD is Manganese (Mn). Cellular and
molecular mechanism of parkinsonism caused by Mn has not been explored clearly. The …