The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

RNA binding proteins (RBPs) have recently emerged as important post-transcriptional gene
expression regulators in both normal development and disease. RBPs influence the fate of …

Acute myeloid leukemia (AML) harboring inv (16)(p13q22) expresses high levels of miR-
126. Here we show that the CBFB-MYH11 (CM) fusion gene upregulates miR-126 …

MiR-126 and miR-155 are key microRNAs (miRNAs) that regulate, respectively,
hematopoietic cell quiescence and proliferation. Herein we showed that in acute myeloid …

Circular RNAs (circRNAs), a type of endogenous noncoding RNA (ncRNA), exert vital roles
in leukemia progression and are promising prognostic factors. Here, we report a novel …

Introns span only a quarter of the human genome, yet they host around 60% of all known
microRNAs. Emerging evidence indicates the adaptive advantage of microRNAs residing …

Spred1 is highly expressed in normal hematopoietic stem cells (HSCs). Lack of Spred1
function has been associated with aberrant hematopoiesis and acute leukemias. In chronic …

The development of venetoclax with HMA has transformed care for elderly adults with AML
and opened the door for novel combinations of venetoclax with other nucleoside analogs …

Background: Acute myeloid leukemia (AML) is characterized as an aggressive blood cancer
with rapid growth of immature leukemic cells. It appears that each subtype of AML displays a …

With the high-quality development of bioinformatics technology, miRNA-disease
associations (MDAs) are gradually being uncovered. At present, convenient and efficient …