Chronic wasting disease in Europe: new strains on the horizon
MA Tranulis, D Gavier-Widén, J Våge… - Acta Veterinaria …, 2021 - Springer
Prion diseases are fatal neurodegenerative disorders with known natural occurrence in
humans and a few other mammalian species. The diseases are experimentally …
humans and a few other mammalian species. The diseases are experimentally …
Recent advances in the histo‐molecular pathology of human prion disease
Prion diseases are progressive neurodegenerative disorders affecting humans and other
mammalian species. The term prion, originally put forward to propose the concept that a …
mammalian species. The term prion, originally put forward to propose the concept that a …
Detection of amyloid fibrils in Parkinson's disease using plasmonic chirality
Amyloid fibrils, which are closely associated with various neurodegenerative diseases, are
the final products in many protein aggregation pathways. The identification of fibrils at low …
the final products in many protein aggregation pathways. The identification of fibrils at low …
Bank vole prion protein as an apparently universal substrate for RT-QuIC-based detection and discrimination of prion strains
CD Orrú, BR Groveman, LD Raymond… - PLoS …, 2015 - journals.plos.org
Prions propagate as multiple strains in a wide variety of mammalian species. The detection
of all such strains by a single ultrasensitive assay such as Real Time Quaking-induced …
of all such strains by a single ultrasensitive assay such as Real Time Quaking-induced …
Studies in bank voles reveal strain differences between chronic wasting disease prions from Norway and North America
Chronic wasting disease (CWD) is a relentless epidemic disorder caused by infectious
prions that threatens the survival of cervid populations and raises increasing public health …
prions that threatens the survival of cervid populations and raises increasing public health …
Human stem cell–derived astrocytes replicate human prions in a PRNP genotype–dependent manner
Prions are infectious agents that cause neurodegenerative diseases such as Creutzfeldt–
Jakob disease (CJD). The absence of a human cell culture model that replicates human …
Jakob disease (CJD). The absence of a human cell culture model that replicates human …
Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp
The atomic structure of the infectious, protease-resistant, β-sheet-rich and fibrillar
mammalian prion remains unknown. Through the cryo-EM method MicroED, we reveal the …
mammalian prion remains unknown. Through the cryo-EM method MicroED, we reveal the …
The molecular determinants of a universal prion acceptor
In prion diseases, the species barrier limits the transmission of prions from one species to
another. However, cross-species prion transmission is remarkably efficient in bank voles …
another. However, cross-species prion transmission is remarkably efficient in bank voles …
The ecology of chronic wasting disease in wildlife
Prions are misfolded infectious proteins responsible for a group of fatal neurodegenerative
diseases termed transmissible spongiform encephalopathy or prion diseases. Chronic …
diseases termed transmissible spongiform encephalopathy or prion diseases. Chronic …
Phenotypic diversity of genetic Creutzfeldt–Jakob disease: a histo-molecular-based classification
The current classification of sporadic Creutzfeldt–Jakob disease (sCJD) includes six major
clinicopathological subtypes defined by the physicochemical properties of the protease …
clinicopathological subtypes defined by the physicochemical properties of the protease …