Inflammatory bowel disease (IBD) affects 6.8 million people globally. A variety of factors
have been implicated in IBD pathogenesis, including host genetics, immune dysregulation …

Glycomics aims to identify the structure and function of the glycome, the complete set of
oligosaccharides (glycans), produced in a given cell or organism, as well as to identify …

A damaging inflammatory response is implicated in the pathogenesis of severe coronavirus
disease 2019 (COVID-19), but mechanisms contributing to this response are unclear. In two …

Abstract The Immunoglobulin G (IgG) glycome is well known for its heterogeneity and shows
a significant degree of variation within populations. IgG glycome composition is influenced …

Despite recent progress in understanding the cancer genome, there is still a relative delay in
understanding the full aspects of the glycome and glycoproteome of cancer. Glycobiology …

Protein glycosylation is a ubiquitous post-translational modification found in all domains of
life. Despite their significant complexity in animal systems, glycan structures have crucial …

Chronic inflammation is the main feature of many long-term inflammatory diseases such as
autoimmune diseases, metabolic disorders, and cancer. There is a growing number of …

Fine structural details of glycans attached to the conserved N-glycosylation site significantly
not only affect function of individual immunoglobulin G (IgG) molecules but also mediate …

BACKGROUND: Non-invasive biomarkers, such as those from serum, are ideal for disease
prognosis, staging and monitoring. In the past decade, our understanding of the importance …

Glycosylation of immunoglobulin G (IgG) influences IgG effector function by modulating
binding to Fc receptors. To identify genetic loci associated with IgG glycosylation, we …