DNA methylation patterns and epigenetic memory
A Bird - Genes & development, 2002 - genesdev.cshlp.org
The character of a cell is defined by its constituent proteins, which are the result of specific
patterns of gene expression. Crucial determinants of gene expression patterns are DNA …
patterns of gene expression. Crucial determinants of gene expression patterns are DNA …
The role of mitochondria in apoptosis
C Wang, RJ Youle - Annual review of genetics, 2009 - annualreviews.org
Mitochondria play key roles in activating apoptosis in mammalian cells. Bcl-2 family
members regulate the release of proteins from the space between the mitochondrial inner …
members regulate the release of proteins from the space between the mitochondrial inner …
[HTML][HTML] Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair
S Cortellino, J Xu, M Sannai, R Moore, E Caretti… - Cell, 2011 - cell.com
DNA methylation is a major epigenetic mechanism for gene silencing. Whereas
methyltransferases mediate cytosine methylation, it is less clear how unmethylated regions …
methyltransferases mediate cytosine methylation, it is less clear how unmethylated regions …
DNA glycosylases: in DNA repair and beyond
AL Jacobs, P Schär - Chromosoma, 2012 - Springer
The base excision repair machinery protects DNA in cells from the damaging effects of
oxidation, alkylation, and deamination; it is specialized to fix single-base damage in the form …
oxidation, alkylation, and deamination; it is specialized to fix single-base damage in the form …
Active DNA demethylation mediated by DNA glycosylases
JK Zhu - Annual review of genetics, 2009 - annualreviews.org
Active DNA demethylation is involved in many vital developmental and physiological
processes of plants and animals. Recent genetic and biochemical studies in Arabidopsis …
processes of plants and animals. Recent genetic and biochemical studies in Arabidopsis …
Uracil in DNA–occurrence, consequences and repair
HE Krokan, F Drabløs, G Slupphaug - Oncogene, 2002 - nature.com
Uracil in DNA results from deamination of cytosine, resulting in mutagenic U: G mispairs,
and misincorporation of dUMP, which gives a less harmful U: A pair. At least four different …
and misincorporation of dUMP, which gives a less harmful U: A pair. At least four different …
Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability
Thymine DNA glycosylase (TDG) is a member of the uracil DNA glycosylase (UDG)
superfamily of DNA repair enzymes. Owing to its ability to excise thymine when mispaired …
superfamily of DNA repair enzymes. Owing to its ability to excise thymine when mispaired …
Chemistry and biology of DNA repair
OD Schärer - Angewandte Chemie International Edition, 2003 - Wiley Online Library
Numerous agents of endogenous and exogenous origin damage DNA in our genome.
There are several DNA‐repair pathways that recognize lesions in DNA and remove them …
There are several DNA‐repair pathways that recognize lesions in DNA and remove them …
Retinoid X receptors: common heterodimerization partners with distinct functions
Retinoid X receptors (RXRs) have been implicated in a diversity of cellular processes
ranging from cellular proliferation to lipid metabolism. These pleiotropic effects stem not only …
ranging from cellular proliferation to lipid metabolism. These pleiotropic effects stem not only …
Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein: implication for the E7-mediated immune evasion mechanism in cervical …
JS Park, EJ Kim, HJ Kwon, ES Hwang… - Journal of Biological …, 2000 - ASBMB
In studying biological roles of interferon regulatory factor (IRF)-1 tumor suppressor in
cervical carcinogenesis, we found that HPV E7 is functionally associated with IRF-1. Binding …
cervical carcinogenesis, we found that HPV E7 is functionally associated with IRF-1. Binding …