The old yellow enzyme (OYE) family is a large group of flavin‐dependent redox biocatalysts
with major applications in the industrial reduction of activated alkenes. These enzymes have …

Redox reactions are essential to any currently known form of life and are at the core of a
majority of metabolic processes, such as cellular respiration or photosynthesis. As about …

The selective enzymatic reduction of nitroaliphatic and nitroaromatic compounds to aliphatic
amines and amino-, azoxy-and azo-aromatics, respectively, remains a persisting challenge …

Asymmetric hydrogenation of activated alkenes catalysed by ene-reductases from the old
yellow enzyme family (OYEs) leading to chiral products is of potential interest for industrial …

Directed evolution utilizing iterative saturation mutagenesis (ISM) has been applied to the
old yellow enzyme homologue YqjM in the quest to broaden its substrate scope, while …

The development of a chiral-at-metal iridium (III) complex for the highly efficient catalytic
asymmetric transfer hydrogenation of β, β′-disubstituted nitroalkenes is reported. Catalysis …

Enantioselective reduction reactions are privileged transformations for the construction of
trisubstituted stereogenic centers. While these include established synthetic strategies, such …

We report the crystal structure of a thermophilic “ene” reductase (TOYE) isolated from
Thermoanaerobacter pseudethanolicus E39. The crystal structure reveals a tetrameric …

Despite the increasing demand for efficient and sustainable chemical processes, the
development of scalable systems using biocatalysis for fine chemical production remains a …

We show that pentaerythritol tetranitrate reductase (PETNR), a member of the 'ene'reductase
old yellow enzyme family, catalyses the asymmetric reduction of a variety of industrially …