DNA methylation-based biomarkers and the epigenetic clock theory of ageing
S Horvath, K Raj - Nature reviews genetics, 2018 - nature.com
Identifying and validating molecular targets of interventions that extend the human health
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …
Integrative analysis of multi-omics data for discovery and functional studies of complex human diseases
YV Sun, YJ Hu - Advances in genetics, 2016 - Elsevier
Complex and dynamic networks of molecules are involved in human diseases. High-
throughput technologies enable omics studies interrogating thousands to millions of makers …
throughput technologies enable omics studies interrogating thousands to millions of makers …
DNA methylation age of human tissues and cell types
S Horvath - Genome biology, 2013 - Springer
Background It is not yet known whether DNA methylation levels can be used to accurately
predict age across a broad spectrum of human tissues and cell types, nor whether the …
predict age across a broad spectrum of human tissues and cell types, nor whether the …
Single-cell genome-wide bisulfite sequencing for assessing epigenetic heterogeneity
We report a single-cell bisulfite sequencing (scBS-seq) method that can be used to
accurately measure DNA methylation at up to 48.4% of CpG sites. Embryonic stem cells …
accurately measure DNA methylation at up to 48.4% of CpG sites. Embryonic stem cells …
ChAMP: 450k chip analysis methylation pipeline
Abstract The Illumina Infinium HumanMethylation450 BeadChip is a new platform for high-
throughput DNA methylation analysis. Several methods for normalization and processing of …
throughput DNA methylation analysis. Several methods for normalization and processing of …
DNA methylation signatures link prenatal famine exposure to growth and metabolism
Periconceptional diet may persistently influence DNA methylation levels with phenotypic
consequences. However, a comprehensive assessment of the characteristics of prenatal …
consequences. However, a comprehensive assessment of the characteristics of prenatal …
Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibility
LE Reinius, N Acevedo, M Joerink, G Pershagen… - PloS one, 2012 - journals.plos.org
Methylation of cytosines at CpG sites is a common epigenetic DNA modification that can be
measured by a large number of methods, now even in a genome-wide manner for hundreds …
measured by a large number of methods, now even in a genome-wide manner for hundreds …
Epigenomic analysis of multilineage differentiation of human embryonic stem cells
Epigenetic mechanisms have been proposed to play crucial roles in mammalian
development, but their precise functions are only partially understood. To investigate …
development, but their precise functions are only partially understood. To investigate …
BSmooth: from whole genome bisulfite sequencing reads to differentially methylated regions
DNA methylation is an important epigenetic modification involved in gene regulation, which
can now be measured using whole-genome bisulfite sequencing. However, cost, complexity …
can now be measured using whole-genome bisulfite sequencing. However, cost, complexity …
Dynamic DNA methylation across diverse human cell lines and tissues
As studies of DNA methylation increase in scope, it has become evident that methylation has
a complex relationship with gene expression, plays an important role in defining cell types …
a complex relationship with gene expression, plays an important role in defining cell types …