Chronic lymphocytic leukemia: revelations from the B-cell receptor

FK Stevenson, F Caligaris-Cappio - Blood, 2004 - ashpublications.org
The finding that chronic lymphocytic leukemia (CLL) consists of 2 clinical subsets,
distinguished by the incidence of somatic mutations in the immunoglobulin (Ig) variable …

B-cell chronic lymphocytic leukemia: a bird of a different feather

F Caligaris-Cappio, TJ Hamblin - Journal of clinical oncology, 1999 - ascopubs.org
PURPOSE: To review the recent major advances in the molecular and cell biology of B-cell
chronic lymphocytic leukemia (B-CLL). METHODS: We analyzed the nature of malignant B …

Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia

L Granziero, P Ghia, P Circosta… - Blood, The Journal …, 2001 - ashpublications.org
In B-cell chronic lymphocytic leukemia (B-CLL), defective apoptosis causes the
accumulation of mature CD5+ B cells in lymphoid organs, bone marrow (BM), and …

Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1

IM Pedersen, S Kitada, LM Leoni… - Blood, The Journal …, 2002 - ashpublications.org
Chronic lymphocytic leukemia (CLL) B cells have defects in apoptosis pathways and
therefore accumulate in vivo. However, when removed from the patient and cultured in vitro …

Importance of crosstalk between chronic lymphocytic leukemia cells and the stromal microenvironment: direct contact, soluble factors, and extracellular vesicles

N Dubois, E Crompot, N Meuleman, D Bron… - Frontiers in …, 2020 - frontiersin.org
Chronic lymphocytic leukemia (CLL) is caused by the accumulation of malignant B cells due
to a defect in apoptosis and the presence of small population of proliferating cells principally …

Chemokine receptors and stromal cells in the homing and homeostasis of chronic lymphocytic leukemia B cells

JA Burger, TJ Kipps - Leukemia & lymphoma, 2002 - Taylor & Francis
Chronic lymphocytic leukemia (CLL) is a disease characterized by an accumulation, of
mature, functionally incompetent B lymphocytes in the blood, secondary lymphoid tissues …

Biology of chronic lymphocytic leukemia in different microenvironments: clinical and therapeutic implications

Y Herishanu, BZ Katz, A Lipsky… - Hematology/Oncology …, 2013 - hemonc.theclinics.com
Biology of Chronic Lymphocytic Leukemia in Different Microenvironments - Hematology/Oncology
Clinics Skip to Main Content Advertisement Hematology/Oncology Clinics Log in Register Log …

Review Role of the microenvironment in chronic lymphocytic leukaemia.

F Caligaris-Cappio - British journal of haematology, 2003 - search.ebscohost.com
Studies the possibility that an important role in favoring the extended survival of malignant
cells involved in chronic lymphocytic leukemia (CLL) might be played by the malignant cell …

Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity

LA Smit, DYH Hallaert, R Spijker, B de Goeij, A Jaspers… - Blood, 2007 - ashpublications.org
The gradual accumulation of chronic lymphocytic leukemia (B-CLL) cells is presumed to
derive from proliferation centers in lymph nodes and bone marrow. To what extent these …

The utility of immunohistochemistry for the identification of hematopoietic and lymphoid cells in normal tissues and interpretation of proliferative and inflammatory …

JE Rehg, D Bush, JM Ward - Toxicologic pathology, 2012 - journals.sagepub.com
Expression of antigens in cells and tissues can be readily studied immunohistochemically
with the use of antibodies. A panel of antibodies to cell-specific markers can be used to …