Mitochondria import many hundreds of different proteins that are encoded by nuclear genes.
These proteins are targeted to the mitochondria, translocated through the mitochondrial …

Ever since the first translocations were recognized in plants and animals in the 1920s,
changes in chromosome structure have been a primary source of information for …

Recognition of targeting signals is a crucial step in protein sorting within the cell. So far, only
a few components capable of deciphering targeting signals have been identified, and …

The Oxa1 protein is a ubiquitous constituent of the inner membrane of mitochondria. Oxa1
was identified in yeast as a crucial component of the protein export machinery known as the …

Precursor proteins of the solute carrier family and of channel forming Tim components are
imported into mitochondria in two main steps. First, they are translocated through the TOM …

The novel genetic method of" sheltered RIP"(repeat induced point mutation) was used to
generate a Neurospora crassa mutant in which MOM19, a component of the protein import …

Transport of nuclear encoded proteins into mitochondria is mediated by multisubunit
translocation machineries in the outer and inner membranes of mitochondria. The TOM …

By using the process of Repeat-induced Point mutation (Selker, EU, and Garrett, PW (1988)
Proc. Natl. Acad. Sci. USA 85, 6870–6874), we inactivated vma-1, the gene encoding …

The import receptor MOM72 constitutes part of the protein translocation machinery of the
outer mitochondrial membrane, the receptor-general insertion pore complex. The protein …

This is an opportune time to evaluate the contributions of Neurospora to genetics and
biology in the recent past and to anticipate what its role might be in the years ahead. The …