Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives
Abstract Type 2 diabetes (T2DM) is a persistent metabolic disorder rising rapidly worldwide.
It is characterized by pancreatic insulin resistance and β-cell dysfunction. Hyperglycemia …
It is characterized by pancreatic insulin resistance and β-cell dysfunction. Hyperglycemia …
The role of oxidative stress and antioxidants in diabetic wound healing
L Deng, C Du, P Song, T Chen, S Rui… - Oxidative medicine …, 2021 - Wiley Online Library
Foot ulcers are one of the most common and severe complication of diabetes mellitus with
significant resultant morbidity and mortality. Multiple factors impair wound healing include …
significant resultant morbidity and mortality. Multiple factors impair wound healing include …
Vascular inflammation and oxidative stress: major triggers for cardiovascular disease
Cardiovascular disease is a leading cause of death and reduced quality of life, proven by
the latest data of the Global Burden of Disease Study, and is only gaining in prevalence …
the latest data of the Global Burden of Disease Study, and is only gaining in prevalence …
Type 2 diabetes mellitus and heart failure: a scientific statement from the American Heart Association and the Heart Failure Society of America: this statement does not …
Type 2 diabetes mellitus is a risk factor for incident heart failure and increases the risk of
morbidity and mortality in patients with established disease. Secular trends in the …
morbidity and mortality in patients with established disease. Secular trends in the …
An overview of the cardiorenal protective mechanisms of SGLT2 inhibitors
T Salvatore, R Galiero, A Caturano, L Rinaldi… - International Journal of …, 2022 - mdpi.com
Sodium-glucose co-transporter 2 (SGLT2) inhibitors block glucose reabsorption in the renal
proximal tubule, an insulin-independent mechanism that plays a critical role in glycemic …
proximal tubule, an insulin-independent mechanism that plays a critical role in glycemic …
Class effects of SGLT2 inhibitors in mouse cardiomyocytes and hearts: inhibition of Na+/H+ exchanger, lowering of cytosolic Na+ and vasodilation
L Uthman, A Baartscheer, B Bleijlevens… - Diabetologia, 2018 - Springer
Aims/hypothesis Sodium–glucose cotransporter 2 (SGLT2) inhibitors (SGLT2i) constitute a
novel class of glucose-lowering (type 2) kidney-targeted agents. We recently reported that …
novel class of glucose-lowering (type 2) kidney-targeted agents. We recently reported that …
Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes
R Chilton, I Tikkanen, CP Cannon… - Diabetes, Obesity …, 2015 - Wiley Online Library
Aims To determine the effects of empagliflozin on blood pressure (BP) and markers of
arterial stiffness and vascular resistance in patients with type 2 diabetes mellitus (T2DM) …
arterial stiffness and vascular resistance in patients with type 2 diabetes mellitus (T2DM) …
Dapagliflozin acutely improves endothelial dysfunction, reduces aortic stiffness and renal resistive index in type 2 diabetic patients: a pilot study
A Solini, L Giannini, M Seghieri, E Vitolo… - Cardiovascular …, 2017 - Springer
Background Sodium-glucose cotransporter-2 inhibitors reduce blood pressure (BP) and
renal and cardiovascular events in patients with type 2 diabetes through not fully elucidated …
renal and cardiovascular events in patients with type 2 diabetes through not fully elucidated …
Effects of SGLT2 inhibitors on systemic and tissue low-grade inflammation: the potential contribution to diabetes complications and cardiovascular disease
F Bonnet, AJ Scheen - Diabetes & metabolism, 2018 - Elsevier
Chronic low-grade inflammation is a recognized key feature associated with type 2 diabetes
mellitus (T2DM) and its complications. In prospective randomized trials, sodium-glucose …
mellitus (T2DM) and its complications. In prospective randomized trials, sodium-glucose …
Short-term e-cigarette vapour exposure causes vascular oxidative stress and dysfunction: evidence for a close connection to brain damage and a key role of the …
M Kuntic, M Oelze, S Steven… - European heart …, 2020 - academic.oup.com
Aims Electronic (e)-cigarettes have been marketed as a 'healthy'alternative to traditional
combustible cigarettes and as an effective method of smoking cessation. There are …
combustible cigarettes and as an effective method of smoking cessation. There are …