Targeting the latent reservoir for HIV-1
S Sengupta, RF Siliciano - Immunity, 2018 - cell.com
Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
Intratumoral heterogeneity: more than just mutations
K Hinohara, K Polyak - Trends in cell biology, 2019 - cell.com
Most human tumors are composed of genetically and phenotypically heterogeneous cancer
cell populations, which poses a major challenge for the clinical management of cancer …
cell populations, which poses a major challenge for the clinical management of cancer …
[HTML][HTML] Single-cell landscape of transcriptional heterogeneity and cell fate decisions during mouse early gastrulation
The mouse inner cell mass (ICM) segregates into the epiblast and primitive endoderm (PrE)
lineages coincident with implantation of the embryo. The epiblast subsequently undergoes …
lineages coincident with implantation of the embryo. The epiblast subsequently undergoes …
Ex vivo analysis identifies effective HIV-1 latency–reversing drug combinations
Reversal of HIV-1 latency by small molecules is a potential cure strategy. This approach will
likely require effective drug combinations to achieve high levels of latency reversal. Using …
likely require effective drug combinations to achieve high levels of latency reversal. Using …
Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice
A Halper-Stromberg, CL Lu, F Klein, JA Horwitz… - Cell, 2014 - cell.com
Latent reservoirs of HIV-1-infected cells are refractory to antiretroviral therapies (ART) and
remain the major barrier to curing HIV-1. Because latently infected cells are long-lived …
remain the major barrier to curing HIV-1. Because latently infected cells are long-lived …
A DNA repair pathway can regulate transcriptional noise to promote cell fate transitions
INTRODUCTION Fluctuations have long been known to dynamically shape microstate
distributions in physical systems. Throughout engineering,“dithering” approaches that …
distributions in physical systems. Throughout engineering,“dithering” approaches that …
An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B …
The persistence of latently infected cells in patients under combinatory antiretroviral therapy
(cART) is a major hurdle to HIV-1 eradication. Strategies to purge these reservoirs are …
(cART) is a major hurdle to HIV-1 eradication. Strategies to purge these reservoirs are …
Perspective: The promise of multi-cellular engineered living systems
Recent technological breakthroughs in our ability to derive and differentiate induced
pluripotent stem cells, organoid biology, organ-on-chip assays, and 3-D bioprinting have all …
pluripotent stem cells, organoid biology, organ-on-chip assays, and 3-D bioprinting have all …
A hardwired HIV latency program
Biological circuits can be controlled by two general schemes: environmental sensing or
autonomous programs. For viruses such as HIV, the prevailing hypothesis is that latent …
autonomous programs. For viruses such as HIV, the prevailing hypothesis is that latent …
Phenotypic noise and plasticity in cancer evolution
Non-genetic alterations can produce changes in a cell's phenotype. In cancer, these
phenomena can influence a cell's fitness by conferring access to heritable, beneficial …
phenomena can influence a cell's fitness by conferring access to heritable, beneficial …