Small molecule-based targeting of chromatin regulatory factors has emerged as a promising
therapeutic strategy in recent years. The development and ongoing clinical evaluation of …

Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-
modifying factors originally identified as part of an epigenetic cellular memory system that …

Abstract The Trithorax group (TrxG) of proteins is a large family of epigenetic regulators that
form multiprotein complexes to counteract repressive developmental gene expression …

Over the past 4 years, nearly 100 exome sequencing studies have revealed the high
frequency of mutations in the genes encoding the subunits of ATP-dependent chromatin …

The role of long noncoding RNA (lncRNA) in adult hearts is unknown; also unclear is how
lncRNA modulates nucleosome remodelling. An estimated 70% of mouse genes undergo …

Subunits of mammalian SWI/SNF (mSWI/SNF or BAF) complexes have recently been
implicated as tumor suppressors in human malignancies. To understand the full extent of …

During the last decade, a host of epigenetic mechanisms were found to contribute to cancer
and other human diseases. Several genomic studies have revealed that∼ 20% of …

Identification of host determinants of coronavirus infection informs mechanisms of viral
pathogenesis and can provide new drug targets. Here we demonstrate that mammalian …

The opposition between Polycomb repressive complexes (PRCs) and BAF (mSWI/SNF)
complexes has a critical role in both development and disease. Mutations in the genes …

Macromolecular assemblies that regulate chromatin structure using the energy of ATP
hydrolysis have critical roles in development, cancer, and stem cell biology. The ATPases of …