Is depression a global brain disorder with topographic dynamic reorganization?

G Northoff, D Hirjak - Translational Psychiatry, 2024 - nature.com
Major depressive disorder (MDD) is characterized by a multitude of psychopathological
symptoms including affective, cognitive, perceptual, sensorimotor, and social. The neuronal …

Deep brain stimulation for refractory major depressive disorder: a comprehensive review

KA Johnson, MS Okun, KW Scangos, HS Mayberg… - Molecular …, 2024 - nature.com
Deep brain stimulation (DBS) has emerged as a promising treatment for select patients with
refractory major depressive disorder (MDD). The clinical effectiveness of DBS for MDD has …

Psilocybin desynchronizes the human brain

JS Siegel, S Subramanian, D Perry, BP Kay… - Nature, 2024 - nature.com
A single dose of psilocybin, a psychedelic that acutely causes distortions of space–time
perception and ego dissolution, produces rapid and persistent therapeutic effects in human …

Frontostriatal salience network expansion in individuals in depression

CJ Lynch, IG Elbau, T Ng, A Ayaz, S Zhu, D Wolk… - Nature, 2024 - nature.com
Decades of neuroimaging studies have shown modest differences in brain structure and
connectivity in depression, hindering mechanistic insights or the identification of risk factors …

Chronic adaptive deep brain stimulation versus conventional stimulation in Parkinson's disease: a blinded randomized feasibility trial

CR Oehrn, S Cernera, LH Hammer, M Shcherbakova… - Nature Medicine, 2024 - nature.com
Deep brain stimulation (DBS) is a widely used therapy for Parkinson's disease (PD) but
lacks dynamic responsiveness to changing clinical and neural states. Feedback control …

Translation of neurotechnologies

G Schalk, P Brunner, BZ Allison, SR Soekadar… - Nature Reviews …, 2024 - nature.com
Neurotechnologies combine engineering methods and neuroscientific knowledge to design
devices that interface the brain with the outside world. Since the early 2000s, inspiring and …

Disruption of neural periodicity predicts clinical response after deep brain stimulation for obsessive-compulsive disorder

NR Provenza, S Reddy, AK Allam, SV Rajesh, N Diab… - Nature Medicine, 2024 - nature.com
Recent advances in surgical neuromodulation have enabled chronic and continuous
intracranial monitoring during everyday life. We used this opportunity to identify neural …

[HTML][HTML] Ethological computational psychiatry: Challenges and opportunities

IE Monosov, J Zimmermann, MJ Frank… - Current opinion in …, 2024 - Elsevier
Studying the intricacies of individual subjects' moods and cognitive processing over
extended periods of time presents a formidable challenge in medicine. While much of …

Brain–computer interfaces for neuropsychiatric disorders

LL Oganesian, MM Shanechi - Nature Reviews Bioengineering, 2024 - nature.com
Neuropsychiatric disorders such as major depression are a leading cause of disability
worldwide with standard treatments, including psychotherapy or medication, failing many …

Automatic assessment method and device for depression symptom severity based on emotional facial expression and pupil-wave

M Li, Z Lu, Q Cao, J Gao, B Hu - IEEE Transactions on …, 2024 - ieeexplore.ieee.org
Depression is a serious mental disorder, significantly burdens individuals, families, and
society. For clinical psychiatrists, assessing the severity of depression is a crucial tool in …