The pathogenesis of many diseases is most closely connected with aberrantly regulated
apoptotic cell death. The past 15 years have witnessed an explosion in the basic knowledge …

Caspases are proteases of clan CD and were described for the first time more than two
decades ago. They play critical roles in the control of regulated cell death pathways …

A series of oxamyl dipeptides were optimized for pan caspase inhibition, anti-apoptotic
cellular activity and in vivo efficacy. This structure− activity relationship study focused on the …

Caspase inhibition has been demonstrated to be therapeutically effective in moderating
excessive programmed cell death, or apoptosis. Publications detailing programs in the …

Caspases are cysteine proteases that specifically cleave Asp− Xxx bonds. They are key
agents in inflammation and apoptosis and are attractive targets for therapy against …

Synthesis, biological evaluation and structure–activity relationships for a series of 2-
substituted 4-methyl-8-(morpholine-4-sulfonyl)-1, 3-dioxo-2, 3-dihydro-1H-pyrrolo [3, 4-c] …

We describe an efficient one-step synthesis of pyrrolo [3, 4-c] quinolinedione derivatives
using ethylenediamine diacetate (EDDA)-catalyzed cascade reactions of isatins and β …

Several caspases have been implicated in the pathogenesis of Huntington's disease (HD);
however, existing caspase inhibitors lack the selectivity required to investigate the specific …

Apoptosis is now recognized as a normal feature in the development of the nervous system
and may also play a role in neurodegenerative disorders, such as Alzheimer's disease. Cell …

A high-throughput screen identified 3-(3, 4-dihydroisoquinolin-2 (1H)-ylsulfonyl) benzoic
acid as a novel, highly potent (low nM), and isoform-selective (1500-fold) inhibitor of aldo …