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Mitochondrial dynamics in health and disease: mechanisms and potential targets
W Chen, H Zhao, Y Li - Signal transduction and targeted therapy, 2023 - nature.com
Mitochondria are organelles that are able to adjust and respond to different stressors and
metabolic needs within a cell, showcasing their plasticity and dynamic nature. These …
metabolic needs within a cell, showcasing their plasticity and dynamic nature. These …
The mitophagy pathway and its implications in human diseases
S Wang, H Long, L Hou, B Feng, Z Ma, Y Wu… - Signal transduction and …, 2023 - nature.com
Mitochondria are dynamic organelles with multiple functions. They participate in necrotic cell
death and programmed apoptotic, and are crucial for cell metabolism and survival …
death and programmed apoptotic, and are crucial for cell metabolism and survival …
[HTML][HTML] Determinants and outcomes of mitochondrial dynamics
Mitochondria are not only central organelles in metabolism and energy conversion but are
also platforms for cellular signaling cascades. Classically, the shape and ultrastructure of …
also platforms for cellular signaling cascades. Classically, the shape and ultrastructure of …
Mitochondria at the crossroads of health and disease
A Suomalainen, J Nunnari - Cell, 2024 - cell.com
Mitochondria reside at the crossroads of catabolic and anabolic metabolism—the essence of
life. How their structure and function are dynamically tuned in response to tissue-specific …
life. How their structure and function are dynamically tuned in response to tissue-specific …
Molecular mechanisms of mitochondrial dynamics
Mitochondria not only synthesize energy required for cellular functions but are also involved
in numerous cellular pathways including apoptosis, calcium homoeostasis, inflammation …
in numerous cellular pathways including apoptosis, calcium homoeostasis, inflammation …
The role of mitochondrial fission in cardiovascular health and disease
JM Quiles, ÅB Gustafsson - Nature Reviews Cardiology, 2022 - nature.com
Mitochondria are organelles involved in the regulation of various important cellular
processes, ranging from ATP generation to immune activation. A healthy mitochondrial …
processes, ranging from ATP generation to immune activation. A healthy mitochondrial …
[HTML][HTML] Quality control of the mitochondrion
Mitochondria are essential organelles that execute and coordinate various metabolic
processes in the cell. Mitochondrial dysfunction severely affects cell fitness and contributes …
processes in the cell. Mitochondrial dysfunction severely affects cell fitness and contributes …
OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy
Cardiomyopathy and heart failure are common manifestations in mitochondrial disease
caused by deficiencies in the oxidative phosphorylation (OXPHOS) system of mitochondria …
caused by deficiencies in the oxidative phosphorylation (OXPHOS) system of mitochondria …
Quality control of the mitochondrial proteome
Abstract Mitochondria contain about 1,000–1,500 proteins that fulfil multiple functions.
Mitochondrial proteins originate from two genomes: mitochondrial and nuclear. Hence …
Mitochondrial proteins originate from two genomes: mitochondrial and nuclear. Hence …
Mitochondrial dynamics in health and disease
In animals, mitochondria are mainly organised into an interconnected tubular network
extending across the cell along a cytoskeletal scaffold. Mitochondrial fission and fusion, as …
extending across the cell along a cytoskeletal scaffold. Mitochondrial fission and fusion, as …