Mitochondrial dynamics in health and disease: mechanisms and potential targets

W Chen, H Zhao, Y Li - Signal transduction and targeted therapy, 2023 - nature.com
Mitochondria are organelles that are able to adjust and respond to different stressors and
metabolic needs within a cell, showcasing their plasticity and dynamic nature. These …

The mitophagy pathway and its implications in human diseases

S Wang, H Long, L Hou, B Feng, Z Ma, Y Wu… - Signal transduction and …, 2023 - nature.com
Mitochondria are dynamic organelles with multiple functions. They participate in necrotic cell
death and programmed apoptotic, and are crucial for cell metabolism and survival …

[HTML][HTML] Determinants and outcomes of mitochondrial dynamics

R Quintana-Cabrera, L Scorrano - Molecular Cell, 2023 - cell.com
Mitochondria are not only central organelles in metabolism and energy conversion but are
also platforms for cellular signaling cascades. Classically, the shape and ultrastructure of …

Mitochondria at the crossroads of health and disease

A Suomalainen, J Nunnari - Cell, 2024 - cell.com
Mitochondria reside at the crossroads of catabolic and anabolic metabolism—the essence of
life. How their structure and function are dynamically tuned in response to tissue-specific …

Molecular mechanisms of mitochondrial dynamics

LC Tábara, M Segawa, J Prudent - Nature Reviews Molecular Cell …, 2025 - nature.com
Mitochondria not only synthesize energy required for cellular functions but are also involved
in numerous cellular pathways including apoptosis, calcium homoeostasis, inflammation …

The role of mitochondrial fission in cardiovascular health and disease

JM Quiles, ÅB Gustafsson - Nature Reviews Cardiology, 2022 - nature.com
Mitochondria are organelles involved in the regulation of various important cellular
processes, ranging from ATP generation to immune activation. A healthy mitochondrial …

[HTML][HTML] Quality control of the mitochondrion

MYW Ng, T Wai, A Simonsen - Developmental cell, 2021 - cell.com
Mitochondria are essential organelles that execute and coordinate various metabolic
processes in the cell. Mitochondrial dysfunction severely affects cell fitness and contributes …

OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy

S Ahola, PR Mejías, S Hermans, S Chandragiri… - Cell metabolism, 2022 - cell.com
Cardiomyopathy and heart failure are common manifestations in mitochondrial disease
caused by deficiencies in the oxidative phosphorylation (OXPHOS) system of mitochondria …

Quality control of the mitochondrial proteome

J Song, JM Herrmann, T Becker - Nature Reviews Molecular Cell …, 2021 - nature.com
Abstract Mitochondria contain about 1,000–1,500 proteins that fulfil multiple functions.
Mitochondrial proteins originate from two genomes: mitochondrial and nuclear. Hence …

Mitochondrial dynamics in health and disease

NMB Yapa, V Lisnyak, B Reljic, MT Ryan - FEBS letters, 2021 - Wiley Online Library
In animals, mitochondria are mainly organised into an interconnected tubular network
extending across the cell along a cytoskeletal scaffold. Mitochondrial fission and fusion, as …