Systemic autoimmune diseases are characterized by the failure of the immune system to
differentiate self from non-self. These conditions are associated with significant morbidity …

The production of neutrophil extracellular traps (NETs) is a process that enables neutrophils
to help catch and kill bacteria. However, increasing evidence suggests that this process …

Neovascularization and vascular remodeling are functionally important for brain repair after
stroke. We show that neutrophils accumulate in the peri-infarct cortex during all stages of …

Systemic autoimmune diseases are a group of disorders characterized by a failure in self-
tolerance to a wide variety of autoantigens. In genetically predisposed individuals, these …

Following fifteen years of research, neutrophil extracellular traps (NETs) are widely reported
in a large range of inflammatory infectious and non-infectious diseases. Cumulating …

In this review, we examine the evidence that neutrophil extracellular traps (NETs) play a
critical role in innate immunity. We summarize how NETs are formed in response to various …

The early events leading to the development of rheumatoid arthritis (RA) remain unclear, but
formation of autoantibodies to citrullinated protein antigens (ACPAs) is considered a key …

Spectacular images of neutrophils ejecting nuclear chromatin and bactericidal proteins, in
response to microbes, were first reported in 2004. As externalized chromatin could entangle …

Regulation of neutrophil activation is critical for disease control. Neutrophil extracellular
traps (NETs), which are web-like structures composed of DNA and neutrophil-derived …

Acute inflammation is a localized and self-limited innate host-defense mechanism against
invading pathogens and tissue injury. Neutrophils, the most abundant immune cells in …