Metabolism is an essential part of life that provides energy for cell growth. During metabolic
flux, reactive electrophiles are produced that covalently modify macromolecules, leading to …

Since the discovery of antimicrobial peptide responses 40 years ago, the fruit fly Drosophila
melanogaster has proven to be a powerful model for the study of innate immunity. Early work …

Type 2 diabetes mellitus (T2D) is a growing health problem, but little is known about its early
disease stages, its effects on biological processes or the transition to clinical T2D. To …

The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …

Alzheimer's disease (AD) and Type 2 Diabetes Mellitus (T2DM) are two of the most
prevalent diseases in the elderly population worldwide. A growing body of epidemiological …

Abstract Noonan syndrome [NS; Mendelian Inheritance in Men (MIM)# 163950] and related
syndromes [Noonan syndrome with multiple lentigines (formerly called LEOPARD …

Physical activity (PA) may modify the genetic effects that give rise to increased risk of
obesity. To identify adiposity loci whose effects are modified by PA, we performed genome …

Organ wasting, related to changes in nutrition and metabolic activity of cells and tissues, is
observed under conditions of starvation and in the context of diseases, including cancers …

More than 25% of human infectious diseases are vector-borne diseases (VBDs). These
diseases, caused by pathogens shared between animals and humans, are a growing threat …

Brain function relies almost solely on glucose as an energy substrate. The main model of
brain metabolism proposes that glucose is taken up and converted into lactate by astrocytes …