Tau in physiology and pathology
Y Wang, E Mandelkow - Nature reviews neuroscience, 2016 - nature.com
Tau is a microtubule-associated protein that has a role in stabilizing neuronal microtubules
and thus in promoting axonal outgrowth. Structurally, tau is a natively unfolded protein, is …
and thus in promoting axonal outgrowth. Structurally, tau is a natively unfolded protein, is …
Tau-targeting therapies for Alzheimer disease
EE Congdon, EM Sigurdsson - Nature Reviews Neurology, 2018 - nature.com
Alzheimer disease (AD) is the most common form of dementia. Pathologically, AD is
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …
SARS‐CoV‐2 targets neurons of 3D human brain organoids
A Ramani, L Müller, PN Ostermann, E Gabriel… - The EMBO …, 2020 - embopress.org
COVID‐19 pandemic caused by SARS‐CoV‐2 infection is a public health emergency.
COVID‐19 typically exhibits respiratory illness. Unexpectedly, emerging clinical reports …
COVID‐19 typically exhibits respiratory illness. Unexpectedly, emerging clinical reports …
Chronic traumatic encephalopathy (CTE): criteria for neuropathological diagnosis and relationship to repetitive head impacts
Over the last 17 years, there has been a remarkable increase in scientific research
concerning chronic traumatic encephalopathy (CTE). Since the publication of NINDS–NIBIB …
concerning chronic traumatic encephalopathy (CTE). Since the publication of NINDS–NIBIB …
Neuroimmunology of traumatic brain injury: time for a paradigm shift
Traumatic brain injury (TBI) is a leading cause of morbidity and disability, with a
considerable socioeconomic burden. Heterogeneity of pathoanatomical subtypes and …
considerable socioeconomic burden. Heterogeneity of pathoanatomical subtypes and …
Applying the Bradford Hill criteria for causation to repetitive head impacts and chronic traumatic encephalopathy
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with a
history of repetitive head impacts (RHI). CTE was described in boxers as early as the 1920s …
history of repetitive head impacts (RHI). CTE was described in boxers as early as the 1920s …
Tau-targeting therapies for Alzheimer disease: current status and future directions
Alzheimer disease (AD) is the most common cause of dementia in older individuals. AD is
characterized pathologically by amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the …
characterized pathologically by amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the …
Traumatic brain injuries
Traumatic brain injuries (TBIs) are clinically grouped by severity: mild, moderate and severe.
Mild TBI (the least severe form) is synonymous with concussion and is typically caused by …
Mild TBI (the least severe form) is synonymous with concussion and is typically caused by …
Tau and neuroinflammation in Alzheimer's disease: Interplay mechanisms and clinical translation
Y Chen, Y Yu - Journal of neuroinflammation, 2023 - Springer
Alzheimer's Disease (AD) contributes to most cases of dementia. Its prominent
neuropathological features are the extracellular neuritic plaques and intercellular …
neuropathological features are the extracellular neuritic plaques and intercellular …
[HTML][HTML] Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy
Pancreatic ductal adenocarcinoma (PDAC) is characterized by notorious resistance to
current therapies attributed to inherent tumor heterogeneity and highly desmoplastic and …
current therapies attributed to inherent tumor heterogeneity and highly desmoplastic and …