Glutamine is the most abundant and versatile amino acid in the body. In health and disease,
the rate of glutamine consumption by immune cells is similar or greater than glucose. For …

Amino acid transporters (AATs) are membrane-bound transport proteins that mediate
transfer of amino acids into and out of cells or cellular organelles. AATs have diverse …

To enable survival in adverse conditions, cancer cells undergo global metabolic
adaptations. The amino acid cysteine actively contributes to cancer metabolic remodelling …

Acute myeloid leukemia (AML) is characterized by the presence of leukemia stem cells
(LSCs), and failure to fully eradicate this population contributes to disease …

Anabolic metabolism mediated by aberrant growth factor signalling fuels tumour growth and
progression. The first biochemical descriptions of the altered metabolic nature of solid …

Prostate cancer is the most frequent nonskin cancer and second most common cause of
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …

As one of the fundamental requirements for cell growth and proliferation, nitrogen
acquisition and utilization must be tightly regulated. Nitrogen can be generated from amino …

Radiotherapy is one of the curative treatment options for localized prostate cancer (PCa).
The curative potential of radiotherapy is mediated by irradiation-induced oxidative stress …

The discovery of the benefits of castration for prostate cancer treatment in 1941 led to
androgen deprivation therapy, which remains a mainstay of the treatment of men with …

Solute carrier (SLC), a diverse family of membrane proteins, are instrumental in
orchestrating the intake and efflux of nutrients including amino acids, vitamins, ions …