Collagen fibrils in the extracellular matrix allow connective tissues such as tendon, skin and
bone to withstand tensile forces. The fibrils are indeterminate in length, insoluble and form …

Protein secretion is an essential process for living organisms. In eukaryotes, this
encompasses numerous steps mediated by several hundred cellular proteins. The core …

H-NS and Lsr2 are nucleoid-associated proteins from Gram-negative bacteria and
Mycobacteria, respectively, that play an important role in the silencing of horizontally …

The coat protein complex I (COPI) allows the precise sorting of lipids and proteins between
Golgi cisternae and retrieval from the Golgi to the ER. This essential role maintains the …

Cranio-lenticulo-sutural dysplasia (CLSD) is an autosomal recessive syndrome
characterized by late-closing fontanels, sutural cataracts, facial dysmorphisms and skeletal …

Cellular processes depend on the fidelity of intracellular membrane traffic. Lipids, proteins,
receptor ligands and solute molecules are trafficked to distinct compartments within the cell …

Pharmacological research has expanded to the nanoscale level with advanced imaging
technologies, enabling the analysis of drug distribution at the cellular organelle level. These …

Calnexin is an endoplasmic reticulum (ER) lectin that mediates protein folding on the rough
ER. Calnexin also interacts with ER calcium pumps that localize to the mitochondria …

Diffusion-mediated searching for interaction partners is an ubiquitous process in cell
biology. Transcription factors, for example, search specific DNA sequences, signaling …

The conserved oligomeric Golgi (COG) complex, a multisubunit tethering complex of the
CATCHR (complexes associated with tethering containing helical rods) family, controls …