Thalassaemia is a diverse group of genetic disorders with a worldwide distribution affecting
globin chain synthesis. The pathogenesis of thalassaemia lies in the unbalanced globin …

Patients suffering from iron overload can experience serious complications. In such patients,
various organs, such as endocrine glands and liver, can be damaged. Although iron is a …

Thalassemic disorders lie on a phenotypic spectrum of clinical severity that depends on the
severity of the globin gene mutation and coinheritance of other genetic determinants. Iron …

Metal ions play important roles in biological processes, 1 and the field of knowledge
concerned with the application of inorganic chemistry to therapy or diagnosis of disease is …

Beta-thalassemia and particularly its transfusion-dependent form (TDT) is a demanding
clinical condition, requiring life-long care and follow-up, ideally in specialized centers and by …

Beta-thalassemias are a group of hereditary blood disorders characterized by anomalies in
the synthesis of the beta chains of hemoglobin resulting in variable phenotypes ranging from …

Beta-thalassemia is caused by the reduced (beta+) or absent (beta 0) synthesis of the beta
globin chains of the hemoglobin tetramer. Three clinical and hematological conditions of …

The purpose of this article is to set forth our approach to diagnosing and managing the
thalassemias, including β-thalassemia intermedia and β-thalassemia major. The article …

This aim of this statement is to report an expert consensus on the diagnosis and treatment of
cardiac dysfunction in β-thalassemia major (TM). This consensus statement does not cover …

Iron is an essential metal for the body, while excess iron accumulation causes organ
dysfunction through the production of reactive oxygen species. There is a sophisticated …