Embryonic stem (ES) cells are cells derived from the early embryo that can be propagated
indefinitely in the primitive undifferentiated state while remaining pluripotent; they share …

Carcinoma in situ testis (CIS), also known as intratubular germ cell neoplasia (ITGCN), is a
pre-invasive precursor of testicular germ cell tumours, the commonest cancer type of male …

The molecular mechanism underlying pluripotency is largely unknown. Here, we provide the
first global transcriptional profile of the state of “stemness” in human embryonic stem cells …

Abstract stella is a novel gene specifically expressed in primordial germ cells, oocytes,
preimplantation embryos, and pluripotent cells [1, 2]. It encodes a protein with a SAP-like …

Genes required to maintain pluripotency in human embryonic stem (hES) cells are largely
unknown, with the exception of OCT‐4, a homolog of mouse Oct‐4, which is critical for the …

It is widely anticipated that human embryonic stem (ES) cells will serve as an experimental
model for studying early development in our species, and, conversely, that studies of …

The head, comprising of the skull and the face, is the most anatomically sophisticated
portion and evolutionary novelty in vertebrates. The most striking feature for the …

Embryonal carcinoma is a histologic subgroup of testicular germ cell tumors (TGCTs), and its
cells may follow differentiation lineages in a manner similar to early embryogenesis. To …

The TGFβ superfamily of ligands plays key functions in development and disease. In both
human and mouse embryonic stem cells, a member of this family, GDF3, is specifically …

Oct4, Nanog, and Stella are transcription factors specifically expressed in embryonic stem
(ES) cells and germ lineage cells that impart critical functions in the maintenance of …