Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …

Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …

Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …

In this Seminar, we highlight the main developments in the field of Alzheimer's disease. The
most recent data indicate that, by 2050, the prevalence of dementia will double in Europe …

Cell death is a fundamental physiological process in all living organisms. Its roles extend
from embryonic development, organ maintenance, and aging to the coordination of immune …

Alzheimer disease (AD) is the most common form of neurodegenerative disease, estimated
to contribute 60–70% of all cases of dementia worldwide. According to the prevailing …

Microglia are emerging as critical regulators of neuronal function and behavior in nearly
every area of neuroscience. Initial reports focused on classical immune functions of …

Increasing evidence points to a pivotal role of immune processes in the pathogenesis of
Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing …

Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The
presence of extracellular β-amyloid deposition as neuritic plaques and intracellular …

Cell death is critical for the development and homeostasis of almost all multicellular
organisms. Moreover, its dysregulation leads to diverse disease states. Historically …